A 803467，NaV1.8 channel blocker (ab120282)
Key features and details
- Selective NaV1.8 channel blocker
- CAS Number: 944261-79-4
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
A 803467，NaV1.8 channel blocker -
描述
Selective NaV1.8 channel blocker -
生物学描述
Selective blocker of NaV1.8 channels (IC50 = 8 nM for human NaV1.8 ). Shows greater than 100-fold selectivity over human NaV1.2, NaV1.3, NaV1.5, and NaV1.7 (IC50 values =1 μM). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive.
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CAS编号
944261-79-4 -
化学结构
性能
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化学名称
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide -
分子量
357.79 -
分子式
C19H16ClNO4 -
PubChem识别号
16038374 -
存放说明
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(Nc1cc(OC)cc(OC)c1)c2ccc(o2)c3ccc(Cl)cc3 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - A 803467, NaV1.8 channel blocker (ab120282)2D chemical structure image of ab120282, A 803467, NaV1.8 channel blocker
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (4)
ab120282 被引用在 4 文献中.
- Mohammed ZA et al. An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery. Pain 161:1100-1108 (2020). PubMed: 31929383
- Yang F et al. SDF1-CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation. J Neuroinflammation 12:219 (2015). PubMed: 26597700
- Ho WS et al. Effective contractile response to voltage-gated Na+ channels revealed by a channel activator. Am J Physiol Cell Physiol 304:C739-47 (2013). PubMed: 23364266
- Ramachandra R et al. Tetrodotoxin-resistant voltage-dependent sodium channels in identified muscle afferent neurons. J Neurophysiol 108:2230-41 (2012). PubMed: 22855776