A 769662，AMP-activated蛋白kinase活化剂(ab120335)
Key features and details
- AMP-activated protein kinase activator
- CAS Number: 844499-71-4
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
A 769662，AMP-activated蛋白kinase活化剂 -
描述
AMP-activated蛋白kinase活化剂 -
生物学描述
Potent, reversible activator of AMP-activated protein kinase (AMPK) (EC50 = 0.8 μM). Directly activates native rat AMPK by mimicking the effects of AMP - it activates AMPK both allosterically and by inhibiting dephosphorylation of AMPK. Shown to inhibit Na+-K+-ATPase at higher concentrations (IC50 = 57 μM) . Inhibits differentiation of adipocytes.
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CAS编号
844499-71-4 -
化学结构
性能
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化学名称
6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile -
分子量
360.39 -
分子式
C20H12N2O3S -
PubChem识别号
54708532 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Oc1ccccc1c2ccc(cc2)c4csc3NC(=O)C(C#N)=C(O)c34 -
来源
Synthetic
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研究领域
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
图片
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Chemical Structure - A 769662, AMP-activated protein kinase activator (ab120335)2D chemical structure image of ab120335, A 769662, AMP-activated protein kinase activator
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (23)
ab120335 被引用在 23 文献中.
- Morrison KR et al. Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin. Open Biol 13:230021 (2023). PubMed: 37042113
- Liao X et al. AMPK phosphorylates NAMPT to regulate NAD+ homeostasis under ionizing radiation. Open Biol 12:220213 (2022). PubMed: 36196536
- Shrikanth CB et al. AMPK differentially alters sulphated glycosaminoglycans under normal and high glucose milieu in proximal tubular cells. J Biochem 169:75-86 (2021). PubMed: 32785657
- Ren Y et al. Oxidative stress-mediated AMPK inactivation determines the high susceptibility of LKB1-mutant NSCLC cells to glucose starvation. Free Radic Biol Med 166:128-139 (2021). PubMed: 33636336
- Gao Y et al. LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate. Gastroenterology 158:1389-1401.e10 (2020). PubMed: 31930988