A 438079，competitive P2X7 receptor拮抗剂(ab120413)
Key features and details
- Potent, competitive P2X7 receptor antagonist
- CAS Number: 899431-18-6
- Purity: > 98%
- Soluble in DMSO to 100 mM and in water to 5 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
A 438079，competitive P2X7 receptor拮抗剂 -
描述
Potent，competitive P2X7 receptor拮抗剂 -
生物学描述
Potent, competitive P2X7 receptor antagonist (pIC50 = 6.5 nM). Shown to reduce pathological nociception.
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纯度
> 98% -
CAS编号
899431-18-6 -
化学结构
性能
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化学名称
3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride -
分子量
342.61 -
分子式
C13H9Cl2N5.HCl -
PubChem识别号
11688742 -
存放说明
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in water to 5 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Clc3cccc(c2nnnn2Cc1cnccc1)c3Cl -
来源
Synthetic
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研究领域
图片
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Chemical Structure - A 438079, competitive P2X7 receptor antagonist (ab120413)2D chemical structure image of ab120413, A 438079, competitive P2X7 receptor antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (4)
ab120413 被引用在 4 文献中.
- Ma Y et al. Potential mechanisms of osteoprotegerin-induced damage to osteoclast adhesion structures via P2X7R-mediated MAPK signaling. Int J Mol Med 49:N/A (2022). PubMed: 35266010
- Wanhainen KM et al. P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy. Cancer Immunol Res 10:871-884 (2022). PubMed: 35588154
- Jiang M et al. P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells. Toxicol Lett 333:22-32 (2020). PubMed: 32721574
- Layhadi JA & Fountain SJ P2X4 Receptor-Dependent Ca2+ Influx in Model Human Monocytes and Macrophages. Int J Mol Sci 18:N/A (2017). PubMed: 29077063