AB120413

A 438079, competitive P2X7 receptor antagonist

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(4 Publications)

MW 342.6 Da, Purity >98%. Potent, competitive P2X₇ receptor antagonist (pIC₅₀ = 6.5 nM). Shown to reduce pathological nociception.

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Chemical Structure - A 438079, competitive P2X7 receptor antagonist (AB120413)

Chemical Structure

Lab

Chemical Structure - A 438079, competitive P2X7 receptor antagonist (AB120413)

2D chemical structure image of ab120413, A 438079, competitive P2X7 receptor antagonist

关键信息

CAS 号

899431-18-6

纯度

>98%

形式

Solid

form

分子量

342.6 Da

分子式

C13H10Cl3N5

PubChem

11688742

属性

Synthetic

溶解度

Soluble in DMSO to 100 mM

Soluble in water to 5 mM

生化试剂名称

A 438079 hydrochloride

生物学描述

Potent, competitive P2X₇ receptor antagonist (pIC₅₀ = 6.5 nM). Shown to reduce pathological nociception.

经典 SMILES

C1=CC(=C(C(=C1)Cl)Cl)C2=NN=NN2CC3=CN=CC=C3.Cl

InChi

InChI=1S/C13H9Cl2N5.ClH/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;/h1-7H,8H2;1H

InChiKey

MBTJFFMIPPMRGR-UHFFFAOYSA-N

IUPAC 名

3-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]pyridine;hydrochloride

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性能和储存信息

运输条件

Ambient - Can Ship with Ice

储存信息

Store under desiccating conditions|The product can be stored for up to 12 months

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Cancer immunology research 10:871-884 PubMed35588154

2022

P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Kelsey M Wanhainen,Changwei Peng,Maggie H Zhou,Bruna de Gois Macedo,Stephen O'Flanagan,Tingyuan Yang,Ameeta Kelekar,Brandon J Burbach,Henrique Borges da Silva,Stephen C Jameson

International journal of molecular medicine 49: PubMed35266010

2022

Potential mechanisms of osteoprotegerin-induced damage to osteoclast adhesion structures via P2X7R-mediated MAPK signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yonggang Ma,Xueni Shi,Hongyan Zhao,Ruilong Song,Hui Zou,Jiaqiao Zhu,Zongping Liu

Toxicology letters 333:22-32 PubMed32721574

2020

P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells.

Applications

Unspecified application

Species

Unspecified reactive species

Min Jiang,Ben-Wen Cui,Yan-Ling Wu,Yu Zhang,Yue Shang,Jian Liu,Hong-Xu Yang,Chun-Ying Qiao,Zi-Ying Zhan,Huan Ye,Quan Jin,Ji-Xing Nan,Li-Hua Lian

International journal of molecular sciences 18: PubMed29077063

2017

P2X4 Receptor-Dependent Ca Influx in Model Human Monocytes and Macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Janice A Layhadi,Samuel J Fountain

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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A 438079, competitive P2X7 receptor antagonist