A-412997 dihydrochloride，D4激动剂

关键信息

CAS 号

1347744-96-0

纯度

>98%

形式

Solid

form

分子量

382.33 g/mol

属性

Synthetic

溶解度

Soluble in water to 100 mM

生物学描述

Highly selective dopamine D₄ receptor agonist at rat D₄ and human D_4.4 receptors (K_i values are 12.1 and 7.9 nM, respectively). Potent, full agonist at rat dopamine D₄ receptors (EC₅₀ = 28.4 nM). Superior selectivity profile to PD168077 (ab120568) and CP226269. No affinity for other dopamine receptors (K_i > 1 μM). Able to rapidly cross the blood-brain barrier following systemic administration.

IUPAC 名

N-(3-Methylphenyl)-2-[4-(2-pyridinyl)-1-piperidinyl]acetamide dihydrochloride