AB141448

8-Br-cAMP (8-Bromo-cAMP), PKA activator

Name: 8-Br-cAMP (8-Bromo-cAMP), PKA活化剂 (ab141448)| Abcam中文官网
Brand: Abcam Limited
SKU: AB141448
Price: 998 CNY
Availability: InStock

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(8 Publications)

MW 430.08 Da, Purity >99%. Cell-permeable cAMP analog. Activates PKA. Inhibits cell growth, decreases proliferation and increases differentiation. Additionally induces apoptosis. Also improves reprogramming efficiency of fibroblast cells.

1 Images

Chemical Structure - 8-Br-cAMP (8-Bromo-cAMP), PKA activator (AB141448)

Chemical Structure

Lab

Chemical Structure - 8-Br-cAMP (8-Bromo-cAMP), PKA activator (AB141448)

2D chemical structure image of ab141448, 8-Br-cAMP (8-Bromo-cAMP), PKA activator

关键信息

CAS 号

76939-46-3

纯度

>99%

形式

Solid

form

分子量

430.08 Da

分子式

C10H10BrN5NaO6P

PubChem

23712387

属性

Synthetic

溶解度

Soluble in water to 100 mM

生化试剂名称

8-bromo-cAMP

生物学描述

Cell-permeable cAMP analog. Activates PKA. Inhibits cell growth, decreases proliferation and increases differentiation. Additionally induces apoptosis. Also improves reprogramming efficiency of fibroblast cells.

经典 SMILES

C1C2C(C(C(O2)N3C4=NC=NC(=C4N=C3Br)N)O)OP(=O)(O1)[O-].[Na+]

InChi

InChI=1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1

InChiKey

DMRMZQATXPQOTP-UHFFFAOYSA-M

IUPAC 名

sodium;6-(6-amino-8-bromopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol

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性能和储存信息

运输条件

Ambient - Can Ship with Ice

储存信息

It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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文献 (8)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine (Cambridge, Mass.) 31:10 PubMed39794729

2025

Decreased expression of LEF1 caused defective decidualization by inhibiting IL-11 expression in patients with adenomyosis.

Applications

Unspecified application

Species

Unspecified reactive species

Jingru Duan,Xiaowei Zhou,Hanfei Zhu,Mingjuan Zhou,Mengyu Liu,Yan Zhou,Wenzhu Li,Bufang Xu,Aijun Zhang

Journal of cellular physiology 239:e31292 PubMed38704705

2024

Primary cilia abnormalities participate in the occurrence of spontaneous abortion through TGF-β/SMAD2/3 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoqin Yu,Linyuan Li,Anfeng Ning,Hu Wang,Chunyi Guan,Xu Ma,Hongfei Xia

Molecular biology reports 49:1701-1710 PubMed35031923

2022

Increased expression of HMGB1 in the implantation phase endometrium is related to recurrent implantation failure.

Applications

Unspecified application

Species

Unspecified reactive species

Mi Han,Yi Cao,Wenjie Zhou,Mingjuan Zhou,Xiaowei Zhou,Dan Zhang,Bufang Xu,Aijun Zhang

Journal of advanced research 30:15-25 PubMed34026283

2021

Decreased PIBF1/IL6/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization.

Applications

Unspecified application

Species

Unspecified reactive species

Mingjuan Zhou,Huihui Xu,Dan Zhang,Chenchen Si,Xiaowei Zhou,Hui Zhao,Qiang Liu,Bufang Xu,Aijun Zhang

Frontiers in physiology 12:642274 PubMed33868005

2021

Diuretic Action of Apelin-13 Mediated by Inhibiting cAMP/PKA/sPRR Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yanting Chen,Chuanming Xu,Jiajia Hu,Mokan Deng,Qixiang Qiu,Shiqi Mo,Yanhua Du,Tianxin Yang

Cancers 12: PubMed33003486

2020

Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander Tishchenko,Daniel D Azorín,Laia Vidal-Brime,María José Muñoz,Pol Jiménez Arenas,Christopher Pearce,Henrique Girao,Santiago Ramón Y Cajal,Trond Aasen

Frontiers in cell and developmental biology 8:105 PubMed32158757

2020

Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaowei Zhou,Bufang Xu,Dan Zhang,Xiaoping Jiang,Hsun-Ming Chang,Peter C K Leung,Xiaoyu Xia,Aijun Zhang

Human reproduction (Oxford, England) 31:2598-2608 PubMed27619769

2016

miR-196a overexpression activates the MEK/ERK signal and represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis.

Applications

Unspecified application

Species

Unspecified reactive species

Min Zhou,Jing Fu,Li Xiao,Shiyuan Yang,Yong Song,Xianghui Zhang,Xue Feng,Huaqin Sun,Wenming Xu,Wei Huang

View all publications

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8-Br-cAMP (8-Bromo-cAMP), PKA activator