8-(3-Chlorostyryl)caffeine，A2A receptor拮抗剂. MAO-B抑制剂.
8-(3-Chlorostyryl)caffeine, A2A receptor antagonist. MAO-B inhibitor.
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MW 330.77 Da, Purity >98%. Selective A2A receptor antagonist and MAO-B (monoamine oxidase B) inhibitor (Ki values are 54 and 100 nM, respectively). Affords strong neuroprotection against 6-OHDA-induced neurotoxicity *in vitro* and is neuroprotective in Parkinson's disease models.
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A1AR, A1R, A2AAR, A2aR, AA1R_HUMAN, AA2AR_HUMAN, AA2BR_HUMAN, ADENO, ADORA 1, ADORA 2, ADORA2A, AHR_HUMAN, Adenosine A2 receptor, Adenosine A2a receptor, Adenosine receptor A1, Adenosine receptor A2a, Adenosine receptor A2b, Adenosine receptor subtype A2a, Ah receptor, Amine oxidase (flavin containing), Amine oxidase (flavin containing) A, Amine oxidase (flavin containing) B, Aromatic hydrocarbon receptor, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor precursor, Class E basic helix-loop-helix protein 76, Eag-related protein 1, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, H-ERG, HGNC:264, HGNC:348, KCNH2_HUMAN, Kv11.1, LQT 2, MAO, MAO-A, MAO-B, Monoamine oxidase, Monoamine oxidase A, Monoamine oxidase B, Monoamine oxidase type A, Monoamine oxidase type B, Netrin 1 receptor, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, RDC 7, RDC 8, Ri, SQT1, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, adora 2b, bHLHe76, eag homolog, hA2aR, hERG-1
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Chemical Structure - 8-(3-Chlorostyryl)caffeine, A2A receptor antagonist. MAO-B inhibitor. (AB120442)
2D chemical structure image of ab120442, 8-(3-Chlorostyryl)caffeine, A2A receptor antagonist. MAO-B inhibitor.
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These receptors and enzymes play roles in signal transduction and neurotransmitter regulation. Adenosine receptors including A2a contribute to vasodilation and anti-inflammatory effects often interacting with caffeine as an antagonist. The Aryl hydrocarbon Receptor mediates cellular responses to external stimuli while Monoamine oxidases degrade neurotransmitters affecting mood and neural activity. These proteins do not always form complexes but interact with various ligands impacting downstream effects.
Pathways
The Adenosine Receptors are integrated into the cAMP signaling pathway influencing heart rate and platelet aggregation. The Aryl hydrocarbon Receptor links to the xenobiotic metabolism pathway interacting with proteins involved in drug metabolism. Monoamine oxidases are part of the dopamine pathway and affect synaptic neurotransmitter levels interconnected with proteins like catechol-O-methyltransferase.
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