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2,3 cis-Piperidine dicarboxylic acid (cis PDA)，Ionotropic receptor拮抗剂(ab120038)

Submit a review Q&A (2)References (1)
Chemical Structure - 2,3 cis-Piperidine dicarboxylic acid (cis PDA), Ionotropic receptor antagonist (ab120038)

    Key features and details

    • Ionotropic receptor antagonist
    • CAS Number: 46026-75-9
    • Soluble in water to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    概述

    • 产品名称

      2,3 cis-Piperidine dicarboxylic acid (cis PDA)，Ionotropic receptor拮抗剂

    • 描述

      Ionotropic receptor拮抗剂

    • 别名

      • cis PDA

    • 生物学描述

      General ionotropic receptor antagonist. Blocks NMDA, AMPA and kainate mediated responses. Also acts as a partial NMDA receptor agonist in the in vitro rat cerebellar cGMP model.

      Also available in simple stock solutions (ab146697) - add 1 ml of water to get an exact, ready-to-use concentration.

    • CAS编号

      46026-75-9

    • 化学结构

      Chemical Structure

    性能

    图片

    • Chemical Structure - 2,3 cis-Piperidine dicarboxylic acid (cis PDA), Ionotropic receptor antagonist (ab120038)
      Chemical Structure - 2,3 cis-Piperidine dicarboxylic acid (cis PDA), Ionotropic receptor antagonist (ab120038)
      2D chemical structure image of ab120038, 2,3 cis-Piperidine dicarboxylic acid (cis PDA), Ionotropic receptor antagonist

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (1)

    发表研究结果有使用 ab120038？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab120038 被引用在 1 文献中.

    • Umino Y  et al. Rod Photoresponse Kinetics Limit Temporal Contrast Sensitivity in Mesopic Vision. J Neurosci 39:3041-3056 (2019). PubMed: 30737308

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    1-2 of 2 Abreviews or Q&A

    Question

    1) Can I use PBS to dissolve both substances?
    2) How much volume of 1M NaOH should I use to neutralize the solution?
    3) Can I prepare a cocktail of both reagents ?

    Read More
    Answer

    Thank you for your enquiry regarding L-AP4 and cis-PDA. The lab send me the following information:

    As we do not currently undertake any of our own research we can only offer advice based on published literature. Both L-AP4 and cis-PDA have been previously dissolved in PBS for use in both rats and rabbits, respectively. It is therefore reasonable to believe that you will be able to use both compounds with PBS in your research. I have attached two papers for your reference.
    I can also provide the following information in reference to neutralizing solutions using 1M NaOH.

    L-AP4
    5.46 μl (1 mg)
    54.6 μl (10 mg)
    273.07 μl (50 mg)

    cis-PDA
    288.73 μl (50 mg)
    1.44 ml (250 mg)


    These values can be calculated using the following formula:
    { Mass of compound (mg) x 1000 } / { MW of compound x [NaOH] } = Vol (ml) NaOH
    In reference to your third point, unfortunately we have not come across previous literature describing a combination of the two compounds used as a cocktail. Since we do not test these combinations in-house I cannot guarantee any in vivo responses, however it is likely that at reasonable physiological concentrations you should see no adverse effects. Please note that you will need to add enough NaOH to neutralize both compounds.
    Please do not hesitate to contact us again if you require further assistance.

    Read More

    Question

    ASC038 BATCH 0612341

    Can you tell me if the product above is:

    1) Dextrorotatory or Levorotatory, or the mixture of both?

    2) If the compound is represented in the R and S system, is this compound (2R,3S0) cis Piperidine dicarboxylic acid or (2S,3R) cis Piperidine dicarboxylic acid or the mixture?

    Read More
    Answer

    I can confirm that cis Piperidine dicarboxylic acid (Asc-038) is a mixture of both Dextrorotatory and Levorotatory and is represented as the mixture.
    I hope this is helpful. Please contact me again if you have any further questions.

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