2-Methoxyestradiol，antitumor and antiangiogenic agent (ab120653)
Key features and details
- Potent antitumor and antiangiogenic agent
- CAS Number: 362-07-2
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
2-Methoxyestradiol，antitumor and antiangiogenic agent -
描述
Potent antitumor and antiangiogenic agent -
生物学描述
Potent antioxidant. Inhibits angiogenesis in vivo with direct cytotoxic effects seen in vitro. Interacts with endothelial tubulin dynamics and increases the expression of death receptor 5 in endothelial cells. Induces apoptosis by p53 induction via activation of p38/JNK pathways.
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纯度
> 98% -
CAS编号
362-07-2 -
化学结构
性能
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化学名称
(17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol -
分子量
302.41 -
分子式
C19H26O3 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- Antioxidants
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
图片
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Chemical Structure - 2-Methoxyestradiol, antitumor and antiangiogenic agent (ab120653)2D chemical structure image of ab120653, 2-Methoxyestradiol, antitumor and antiangiogenic agent
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120653 被引用在 1 文献中.
- Liu J et al. CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1a-Mediated Glycolysis. Immunity 50:600-615.e15 (2019). PubMed: 30824325