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2-Chloro-N6-cyclopentyladenosine (CCPA)，A1激动剂(ab120434)

Submit a review Q&A (2)References (2)
Chemical Structure - 2-Chloro-N6-cyclopentyladenosine (CCPA), A<sub>1</sub> agonist (ab120434)

    Key features and details

    • Highly potent, selective A1 agonist
    • CAS Number: 37739-05-2
    • Soluble in water to 5 mM and in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    概述

    • 产品名称

      2-Chloro-N6-cyclopentyladenosine (CCPA)，A1激动剂

    • 描述

      Highly potent，selective A1激动剂

    • 别名

      • CCPA

    • 生物学描述

      Highly potent and selective A1 receptor agonist (Ki values are 0.8, 2300 and 42 nM for human A1, A2A and A3 receptors, respectively). Shows >2000-fold selectivity over A2A. Centrally active following systemic administration and anticonvulsive in vivo.

    • CAS编号

      37739-05-2

    • 化学结构

      Chemical Structure

    性能

    图片

    • Chemical Structure - 2-Chloro-N6-cyclopentyladenosine (CCPA), A<sub>1</sub> agonist (ab120434)
      Chemical Structure - 2-Chloro-N6-cyclopentyladenosine (CCPA), A1 agonist (ab120434)
      2D chemical structure image of ab120434, 2-Chloro-N6-cyclopentyladenosine (CCPA), A1 agonist

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (2)

    发表研究结果有使用 ab120434？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab120434 被引用在 2 文献中.

    • Fujimoto K  et al. Adenosine Attenuates Aortic Smooth Muscle Cell Calcification through A3 Adenosine Receptor. Tohoku J Exp Med 249:275-283 (2019). PubMed: 31875581
    • Yi X  et al. Adenosine receptors enhance the ATP-induced odontoblastic differentiation of human dental pulp cells. Biochem Biophys Res Commun 497:850-856 (2018). PubMed: 29454963

    客户评价及客户问答

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    1-2 of 2 Abreviews or Q&A

    Question


    Inquiry: I prepare to order CCPA (ab120434) from your company. I would like to know whether CCPA is soluble in PBS or 0.9% saline? Thank you for your time and help.

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    Answer

    Thank you for contacting us.



    The datasheet for this product states that it is soluble in water to 5 mM, this indicates that it should also be soluble in PBS or saline.



    Depending on the assay, I would also advise you to double check the literature for similar assays.

    This paper dissolved CCPA in 0.9% saline:

    http://circ.ahajournals.org/content/101/24/2841.full.pdf



    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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    Question

    we received the product 2-Chloro-N6-cyclopentyladenosine batch: APN10174-1-3 from you, thank you very much.
    Please can you let me know what the water content of this batch is, because you wrote at the molecular formula that the product includes 0.5H2O.

    Thanks for your help
    Best regards

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    Answer

    Thank you for your email last week and for your patience while I have been in touch with the lab about your enquiry.

    The compound contains 0.5 moles of water per mole of compound. This equates to 2.38% water by weight.

    I hope this informationwill be useful, but please let me know if you have any furtherquestions or if there is anythingelse that we can do for you.

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