2-APB，Ca2+ release modulator (ab120124)
Key features and details
- Ca2+ release modulator
- CAS Number: 524-95-8
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
2-APB，Ca2+ release modulator -
描述
Ca2+ release modulator -
生物学描述
Cell-permeable, allosteric inhibitor of D-myo-inositol 1,4,5-trisphosphate (IP3) -induced Ca2+ release . Inhibits IP3-induced Ca2+ release without affecting IP3 receptor binding. Blocks store operated Ca2+ entry.
-
CAS编号
524-95-8 -
化学结构
性能
-
化学名称
2-Aminoethyl diphenylborinate -
分子量
225.10 -
分子式
C14H16BNO -
PubChem识别号
1598 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
NCCOB(c1ccccc1)c2ccccc2 -
来源
Synthetic
-
研究领域
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Vitamin D Receptor
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipases
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Inositol lipids
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Inositol lipids
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Inositol lipids
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- Inositol & cAMP signaling
- Inositol lipids
图片
-
Chemical Structure - 2-APB, Ca2+ release modulator (ab120124)2D chemical structure image of ab120124, 2-APB, Ca2+ release modulator
-
Functional Studies - 2-APB, Ca2+ release modulator (ab120124)Kubota et al PLoS One. 2014; 9(9): e106316. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Induction of mGluR1-mediated inward current requires activation of TRPC1 but not TRPC3 in MLIs.
Time courses of the effects of SKF96365 (black circles, 30 µM, n = 4) and 2-APB (gray circles, 100 µM, n = 5) on the DHPG-induced inward current. A black bar indicates the time of drug application.
(From Figure 2 B of Kubota et al).
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (19)
ab120124 被引用在 19 文献中.
- Yang J et al. Mitochondria-associated membrane protein PACS2 maintains right cardiac function in hypobaric hypoxia. iScience 26:106328 (2023). PubMed: 36968068
- Lin C et al. Functional imaging-guided cell selection for evolving genetically encoded fluorescent indicators. Cell Rep Methods 3:100544 (2023). PubMed: 37671014
- Li C et al. PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity. Front Cell Dev Biol 10:896014 (2022). PubMed: 35874841
- Andriulė I et al. Detection of TRPM6 and TRPM7 Proteins in Normal and Diseased Cardiac Atrial Tissue and Isolated Cardiomyocytes. Int J Mol Sci 23:N/A (2022). PubMed: 36499188
- Dantas M et al. Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation. J Cell Biol 221:N/A (2022). PubMed: 36222828