1400W，iNOS抑制剂(ab120165)
Key features and details
- Selective iNOS inhibitor
- CAS Number: 214358-33-5
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
1400W，iNOS抑制剂 -
描述
Selective iNOS抑制剂 -
生物学描述
Selective iNOS inhibitor, 5000-fold selective over eNOS (Kd values are ≤7 nM, 2 μM and 50 μM at human iNOS, nNOS and eNOS, respectively).
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CAS编号
214358-33-5 -
化学结构
性能
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化学名称
N-[3-(Aminomethyl)benzyl]acetamidine dihydrochloride -
分子量
250.17 -
分子式
C10H15N3.2HCl -
PubChem识别号
2733515 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cl.CC(=N)NCc1cccc(c1)CN -
来源
Synthetic
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研究领域
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- NOS
- Inhibitors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
相关产品
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图片
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Chemical Structure - 1400W, iNOS inhibitor (ab120165)2D chemical structure image of ab120165, 1400W, iNOS inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (5)
ab120165 被引用在 5 文献中.
- Simpson DS et al. Interferon-? primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity 55:423-441.e9 (2022). PubMed: 35139355
- Xian Bo S et al. An Inducible Nitric Oxide Synthase Dimerization Inhibitor Prevents the Progression of Osteoarthritis. Front Pharmacol 13:861183 (2022). PubMed: 35910349
- Liu L et al. Inhibition of inducible nitric oxide synthase improved erectile dysfunction in rats with type 1 diabetes. Andrologia 53:e14138 (2021). PubMed: 34137064
- Jiang L et al. Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate. Redox Biol 43:101989 (2021). PubMed: 33940548
- Tanemoto R et al. The constituents of licorice (Glycyrrhiza uralensis) differentially suppress nitric oxide production in interleukin-1ß-treated hepatocytes. Biochem Biophys Rep 2:153-159 (2015). PubMed: 29124157