(+)-MK 801 maleate (Dizocilpine)，Non-competitive NMDA拮抗剂(ab120027)
Key features and details
- Non-competitive NMDA antagonist
- CAS Number: 77086-22-7
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
(+)-MK 801 maleate (Dizocilpine)，Non-competitive NMDA拮抗剂 -
描述
Non-competitive NMDA拮抗剂 -
别名
- Dizocilpine
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生物学描述
Potent, selective non-competitive NMDA receptor antagonist. Open channel blocker of the NMDA receptor operated ion channel.
Also available in simple stock solutions (ab144485) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
77086-22-7 -
化学结构
性能
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化学名称
(5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate -
分子量
337.37 -
分子式
C16H15N.C4H4O4 -
PubChem识别号
6420042 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)/C=CC(=O)O.C[C@@]42N[C@H](Cc1ccccc12)c3ccccc34 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - (+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist (ab120027)2D chemical structure image of ab120027, (+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist
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Functional Studies - (+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist (ab120027)Image from Fowler SW et al., Neurobiol Learn Mem. 2010;95(1):73-9. Fig 2(B).; doi: 10.1016/j.nlm.2010.11.009 with permission from Elsevier.CDPPB does not influence spontaneous locomotor activity but attenuates MK-801-induced hyperlocomotion. Animals were injected (s.c./i.p.) with PBS/Vehicle (0/0), 0.2 mg/kg MK-801/Vehicle (0.2/0), 0.2 mg/kg MK-801/3 mg/kg CDPPB (0.2/3) or 0.2 mg/kg MK-801/10 mg/kg CDPPB (0.2/10) 20 minutes before being placed in the activity chamber. Activity was recorded for 30 minutes. Data are expressed as mean ± SEM of distance traveled (n=6-7). **p<0.01 vs. 0.2 mg/kg MK-801/Vehicle group (One-way ANOVA, Bonferroni’s posttest).
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (43)
ab120027 被引用在 43 文献中.
- Iorgu AM et al. Psilocybin does not induce the vulnerability marker HSP70 in neurons susceptible to Olney's lesions. Eur Arch Psychiatry Clin Neurosci 274:1013-1019 (2024). PubMed: 37934233
- Kayir H et al. Clozapine Increases Nestin Concentration in the Adult Male Rat Hippocampus: A Preliminary Study. Int J Mol Sci 23:N/A (2022). PubMed: 35408792
- Pampaloni NP et al. Slow AMPA receptors in hippocampal principal cells. Cell Rep 36:109496 (2021). PubMed: 34348150
- Lee GS et al. Behavioral and Neuroanatomical Consequences of Cell-Type Specific Loss of Dopamine D2 Receptors in the Mouse Cerebral Cortex. Front Behav Neurosci 15:815713 (2021). PubMed: 35095443
- Wang EY & Lai TW Drug-Induced Hyperglycemia as a Potential Contributor to Translational Failure of Uncompetitive NMDA Receptor Antagonists. eNeuro 8:N/A (2021). PubMed: 34862204