(+)-Bicuculline，GABAA拮抗剂(ab120107)
Key features and details
- GABAA antagonist
- CAS Number: 485-49-4
- Soluble in ethanol to 5 mM and DMSO to 100 mM (with heating)
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
(+)-Bicuculline，GABAA拮抗剂 -
描述
GABAA拮抗剂 -
生物学描述
GABAA antagonist.
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CAS编号
485-49-4 -
化学结构
性能
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化学名称
[R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one -
分子量
367.35 -
分子式
C20H17NO6 -
PubChem识别号
10237 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in ethanol to 5 mM and DMSO to 100 mM (with heating) -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN2CCc1cc6OCOc6cc1[C@H]2[C@@H]5OC(=O)c4c5ccc3OCOc34 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - (+)-Bicuculline, GABAA antagonist (ab120107)2D chemical structure image of ab120107, (+)-Bicuculline, GABAA antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (35)
ab120107 被引用在 35 文献中.
- Topczewska A et al. T-type Ca2+ and persistent Na+ currents synergistically elevate ventral, not dorsal, entorhinal cortical stellate cell excitability. Cell Rep 42:112699 (2023). PubMed: 37368752
- Mishra P & Narayanan R Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells. iScience 25:103922 (2022). PubMed: 35252816
- Schröter M et al. Functional imaging of brain organoids using high-density microelectrode arrays. MRS Bull 47:530-544 (2022). PubMed: 36120104
- Blazon M et al. N-type calcium channels control GABAergic transmission in brain areas related to fear and anxiety. OBM Neurobiol 5:N/A (2021). PubMed: 33521586
- Dingle YL et al. Integrated functional neuronal network analysis of 3D silk-collagen scaffold-based mouse cortical culture. STAR Protoc 2:100292 (2021). PubMed: 33537680