(-)-Bicuculline methiodide，GABAA拮抗剂(ab120108)
Key features and details
- GABAA antagonist
- CAS Number: 40709-69-1
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
(-)-Bicuculline methiodide，GABAA拮抗剂 -
描述
GABAA拮抗剂 -
CAS编号
40709-69-1 -
化学结构
性能
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化学名称
[S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide -
分子量
509.29 -
分子式
C21H20INO6 -
PubChem识别号
185826 -
存放说明
Store at +4°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
To be used on the same day after reconstitution.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[I-].C[N+]5(C)CCc1cc6OCOc6cc1[C@@H]5[C@H]4OC(=O)c3c4ccc2OCOc23 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - (-)-Bicuculline methiodide, GABAA antagonist (ab120108)2D chemical structure image of ab120108, (-)-Bicuculline methiodide, GABAA antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (33)
ab120108 被引用在 33 文献中.
- Eichler A et al. Microglial Cytokines Mediate Plasticity Induced by 10 Hz Repetitive Magnetic Stimulation. J Neurosci 43:3042-3060 (2023). PubMed: 36977586
- Lenz M et al. Denervated mouse CA1 pyramidal neurons express homeostatic synaptic plasticity following entorhinal cortex lesion. Front Mol Neurosci 16:1148219 (2023). PubMed: 37122623
- Zheng R et al. KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization. Elife 11:N/A (2022). PubMed: 35138249
- Yong XLH et al. Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIa phosphorylation of the GluN2A subunit. Cell Rep 36:109338 (2021). PubMed: 34233182
- Conde-Dusman MJ et al. Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly. Elife 10:N/A (2021). PubMed: 34787081