AB197463

小鼠Cytokine抗体阵列(200 Targets) - Quantitative

Name: 小鼠Cytokine抗体阵列(200 Targets) - Quantitative (ab197463)| Abcam中文官网
Brand: Abcam Limited
SKU: AB197463
Price: 134258 CNY
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Mouse Cytokine Antibody Array (200 Targets) - Quantitative

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ab197463 can be used for quantitative measurement of 200 Mouse cytokines.

查看别名

CD143, Dcp1, Ace, Angiotensin-converting enzyme, ACE, Dipeptidyl carboxypeptidase I, Kininase II

关键信息

检测类型

Quantitative

反应种属

Mouse

靶标

Ace

target

检测方法

Fluorescent

检测平台

Multiplex

样品类型

Tissue Lysate, Plasma, Cell culture media, Serum, Other biological fluids, Cell Lysate

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产品详情

ab197463 can be used for quantitative measurement of 200 Mouse cytokines. Suitable for serum, plasma, cell culture media, other body fluids, cell and tissue lysates.

Targets names:
Array A: Axl, CD27L, CD30T, CD40, CXCL16, EGF, E-selectin, Fractalkine, GITR, HGF, IGFBP-2, IGFBP-3, IGFBP-5, IGFBP-6, IGF-I, IL-12p70, IL-17E, IL-17F, IL-1ra, IL-2 Rα, IL-20, IL-23, IL-28, I-TAC, MDC, MIP-2, MIP-3α, OPN, OPG, Prolactin, Pro-MMP-9, P-selectin, Resistin, SCF, SDF-1α, TPO, VCAM-1, VEGF, VEGF-D.

Array B: bFGF, BLC, CD30L, Eotaxin, Eotaxin-2, Fas L, GCSF, GM-CSF, ICAM-1, IFNγ, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-10, IL-12p40, IL-13, IL-15, IL-17, IL-21, KC, Leptin, LIX, MCP-1, MCP-5, M-CSF, MIG, MIP-1α, MIP-1γ, PF-4, RANTES, TARC, TCA-3, TNFα, TNFRI, TNFRII.

Array C: 4-1BB, ACE, ALK-1, CT-1, CD27, CD40L, CTLA-4, Decorin, Dkk-1, Dtk, Endoglin, Fcγ RIIB, Flt-3 L, Galectin-1, Galectin-3, Gas 1, Gas 6, GITR L, HAI-1, HGF R, IL-1 R4, IL-3 Rβ, IL-9, JAM-A, Leptin R, L Selectin, Lymphotactin, MadCAM-1, MFG-E8, MIP-3β, Neprilysin, Pentraxin 3, RAGE, TACI, TREM-1, TROY, TSLP, TWEAK R, VEGF R1, VEGF R3.

Array D: B7-1, BAFF R, BTC, C5a, CCL6, CD48, CD6, Chemerin, Clusterin, CXCL15, Cystatin C, DAN, DLL4, EDAR, Endocan, Fetuin A, H60, IL-33, IL-7 Ralpha, Kremen-1, Limitin, Lipocalin-2, LOX-1, Marapsin, MBL-2, Meteorin, Nope, NOV, Osteoactivin, OX40, Ligand, P-Cadherin, Periostin, PlGF-2, Progranulin, Prostasin, Renin 1, Testican 3, TIM-1, TRAIL, Tryptase epsilon.

Array E: 6Ckine, Activin A, ADAMTS1, Adiponectin, ANG-3, ANGPTL3, Artemin, CCL28, CD36, Chordin, CRP, E-Cadherin, Epigen, Epiregulin, Fas, Galectin-7, gp130, Granzyme B, Gremlin, IFN-γ R1, IL-17B, IL-17B R, IL-22, MIP-1β, MMP-2, MMP-3, MMP-10, PDGF-AA, Persephin, sFRP-3, Shh-N, SLAM, TCK-1, TECK, TGFβ1, TRANCE, TremL1, TWEAK, VEGF-B, VEGF-R2.

Quantitative antibody arrays can be used to quantitate up to 40 cytokines with as little as 50 µL of sample. Arrays are available for 400 human and 200 mouse proteins. Each glass slide is spotted with 16 identical antibody arrays and is provided with a 16 well gasket to allow separate samples to be applied to each array. Each antibody is spotted in quadruplicate in each array. For reproducible quantitation, eight of the arrays are used with a cocktail of protein standards to produce a standard curve. The same 8 standard curve arrays can be used across multiple slides, allowing measurement of 22 experimental samples with 2 slides, 36 with 3 slides etc. For high through-put, 4 slides can be nested into a tray matching a standard microplate, allowing automated processing with a liquid handling workstation. Array processing can be completed within one working day (see workflow diagram below) and arrays can be analyzed with a wide number of laser glass slide array / gene microarray scanners. If you don’t have a suitable scanner then we recommend our membrane antibody arrays, which can be analyzed with any WB chemiluminescent reader. The standard is affinity purified.

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规格

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性能和储存信息

运输条件

Blue Ice

储存信息

-20°C

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产品实验方案

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靶点信息

Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity (PubMed : 11723129, PubMed : 12777443, PubMed : 14757757, PubMed : 16270063, PubMed : 35201898, PubMed : 7753170, PubMed : 8642790, PubMed : 9231832). Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates (PubMed : 11303049). Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin (PubMed : 11303049, PubMed : 14757757, PubMed : 9231832). Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response (By similarity). Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins (By similarity). Catalyzes degradation of different enkephalin neuropeptides (Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Phe and possibly Met-enkephalin-Arg-Gly-Leu) (PubMed : 35201898). Acts as a regulator of synaptic plasticity in the nucleus accumbens of the brain by mediating cleavage of Met-enkephalin-Arg-Phe, a strong ligand of Mu-type opioid receptor OPRM1, into Met-enkephalin (PubMed : 35201898). Met-enkephalin-Arg-Phe cleavage by ACE decreases activation of OPRM1, leading to long-term synaptic potentiation of glutamate release (PubMed : 35201898). Also acts as a regulator of hematopoietic stem cell differentiation by mediating degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) (PubMed : 11303049). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). Involved in amyloid-beta metabolism by catalyzing degradation of Amyloid-beta protein 40 and Amyloid-beta protein 42 peptides, thereby preventing plaque formation (By similarity). Catalyzes cleavage of cholecystokinin (maturation of Cholecystokinin-8 and Cholecystokinin-5) and Gonadoliberin-1 (both maturation and degradation) hormones (By similarity). Degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) and amyloid-beta proteins is mediated by the N-terminal catalytic domain, while angiotensin I and cholecystokinin cleavage is mediated by the C-terminal catalytic region (PubMed : 11303049).. Angiotensin-converting enzyme, soluble form. Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region.. Isoform Testis-specific. Isoform produced by alternative promoter usage that is specifically expressed in spermatocytes and adult testis, and which is required for male fertility (PubMed : 1651914, PubMed : 9482924). In contrast to somatic isoforms, only contains one catalytic domain (PubMed : 16270063). Acts as a dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of substrates (PubMed : 16270063). The identity of substrates that are needed for male fertility is unknown (PubMed : 16270063). Isoform Testis-specific and isoform Somatic have distinct activities and cannot completely compensate for the loss of the other when expressed in somatic tissues or testis (PubMed : 10831599, PubMed : 11723129, PubMed : 12777443, PubMed : 16270063, PubMed : 9664078). May also have a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (PubMed : 15665832). The GPIase activity was reported to be essential for the egg-binding ability of the sperm (PubMed : 15665832). This activity is however unclear and has been challenged by other groups, suggesting that it may be indirect (PubMed : 16270063).

See full target information Ace

其他靶点

A disintegrin and metalloproteinase with thrombospondin motifs 1,Shh,Vascular endothelial growth factor B,,Angptl1,Ccl21b,Chrd,Csf2rb,Ereg,Grem1,,Inhba,,,Adipoq,,Ccl1,Ccl12,Ccl2,Ccl3,Ccl9,Cd40,Cd48,Cst3,Ctla4,Cxcl15,Cxcl16,Dkk1,,Egf,F11r,Fas,Vegfd,Flt1,Frzb,Gas6,Havcr1,Hgf,Igfbp6,Il10,Il17a,Il17b,Il1rl1,Il2,Il22,Il2ra,Lcn2,Lgals1,Madcam1,Metrn,Mfge8,Mme,Mmp9,Retinoic acid receptor responder protein 2,Slamf1,Slpi,Spp1,Tnf,Tnfrsf11b,Tnfrsf13b,Tnfrsf18,,Tnfrsf1b,Tnfsf11,Trem1,,,,,H60a,,,Il7r,,,,Lgals7,,,,,,,,,,,,,,,,,,,,,,,Il1rl1,,,,,,,,H60a,,,,,,,,,,Il17a,Lepr,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Il7r,,,Ccl17,,,,,,,,,,,,,,,,Il1rl1,,,,,,,,H60a,,,,,,,,,,Il17a,Lepr,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Il7r,,,Ccl17,Ahsg,Angiopoietin-related protein 3,Axl,Btc,C5,Ccl11,Ccl19,Ccl20,Ccl22,Ccl24,Ccl25,Ccl28,Ccl4,Ccl5,Ccl6,Cd27,Cd36,Cd40lg,T-cell differentiation antigen CD6,CD70,Cd80,Cdh1,Clu,Crp,Csf1,Csf3,Ctf1,Cx3cl1,Cxcl1,Cxcl11,Cxcl12,Cxcl13,Cxcl2,Cxcl5,Cxcl9,Dcn,Dll4,Eng,Endothelial cell-specific molecule 1,Faslg,Fcgr2,Fgf2,Flt3lg,Flt4,Gas1,Gpnmb,Grn,Icam1,Ifna11,Ifng,Ifngr1,Ifnl2,Igf1,Igfbp2,Igfbp3,Igfbp5,Il12a,Il12b,Il13,Il17f,Il17rb,IL1A_MOUSE,Il1b,Il1rn,Il20,Il23a,IL-25,Il3,Il33,Il4,Il5,Il6,Il6st,Il7,Il9,Kitlg,Lep,Mbl2,Mmp10,Mmp2,Mmp3,Ccn3,Olr1,Pdgfa,Pf4,Pgf,Postn,CXCL7/PBP,Prl,,Ptx3,Retn,Sele,Selp,Spint1,Tgfb1,Thpo,Tnfrsf13c,Tnfrsf1a,Tnfrsf8,Tnfrsf9,Tnfsf10,Tnfsf12,Tnfsf18,Tnfsf4,Tnfsf8,Treml1,Tslp,Vcam1,Vegfa,Xcl1

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文献 (1)

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小鼠Cytokine抗体阵列(200 Targets) - Quantitative

Mouse Cytokine Antibody Array (200 Targets) - Quantitative

关键信息

检测类型

反应种属

靶标

检测方法

检测平台

样品类型

产品详情