AB197462

小鼠Cytokine抗体阵列(160 Targets) - Quantitative

Name: 小鼠Cytokine抗体阵列(160 Targets) - Quantitative (ab197462)| Abcam中文官网
Brand: Abcam Limited
SKU: AB197462
Price: 109584 CNY
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Mouse Cytokine Antibody Array (160 Targets) - Quantitative

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ab197462 can be used for quantitative measurement of 160 Mouse cytokines.

查看别名

Rage, Ager, Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products

关键信息

检测类型

Quantitative

反应种属

Mouse

靶标

Ager

target

检测方法

Fluorescent

检测平台

Multiplex

样品类型

Tissue Lysate, Plasma, Cell culture media, Serum, Other biological fluids, Cell Lysate

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产品详情

ab197462 can be used for quantitative measurement of 160 Mouse cytokines. Suitable for serum, plasma, cell culture media, other body fluids, cell and tissue lysates.

Targets names:
Array A: Axl, CD27L, CD30T, CD40, CXCL16, EGF, E-selectin, Fractalkine, GITR, HGF, IGFBP-2, IGFBP-3, IGFBP-5, IGFBP-6, IGF-I, IL-12p70, IL-17E, IL-17F, IL-1ra, IL-2 Rα, IL-20, IL-23, IL-28, I-TAC, MDC, MIP-2, MIP-3α, OPN, OPG, Prolactin, Pro-MMP-9, P-selectin, Resistin, SCF, SDF-1α, TPO, VCAM-1, VEGF, VEGF-D.
Array B: bFGF, BLC, CD30L, Eotaxin, Eotaxin-2, Fas L, GCSF, GM-CSF, ICAM-1, IFNγ, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-10, IL-12p40, IL-13, IL-15, IL-17, IL-21, KC, Leptin, LIX, MCP-1, MCP-5, M-CSF, MIG, MIP-1α, MIP-1γ, PF-4, RANTES, TARC, TCA-3, TNFα, TNFRI, TNFRII.
Array C: 4-1BB, ACE, ALK-1, CT-1, CD27, CD40L, CTLA-4, Decorin, Dkk-1, Dtk, Endoglin, Fcγ RIIB, Flt-3 L, Galectin-1, Galectin-3, Gas 1, Gas 6, GITR L, HAI-1, HGF R, IL-1 R4, IL-3 Rβ, IL-9, JAM-A, Leptin R, L Selectin, Lymphotactin, MadCAM-1, MFG-E8, MIP-3β, Neprilysin, Pentraxin 3, RAGE, TACI, TREM-1, TROY, TSLP, TWEAK R, VEGF R1, VEGF R3.
Array D: B7-1, BAFF R, BTC, C5a, CCL6, CD48, CD6, Chemerin, Clusterin, CXCL15, Cystatin C, DAN, DLL4, EDAR, Endocan, Fetuin A, H60, IL-33, IL-7 Ralpha, Kremen-1, Limitin, Lipocalin-2, LOX-1, Marapsin, MBL-2, Meteorin, Nope, NOV, Osteoactivin, OX40, Ligand, P-Cadherin, Periostin, PlGF-2, Progranulin, Prostasin, Renin 1, Testican 3, TIM-1, TRAIL, Tryptase epsilon.

Quantitative antibody arrays can be used to quantitate up to 40 cytokines with as little as 50 μL of sample. Arrays are available for 400 human and 200 mouse proteins. Each glass slide is spotted with 16 identical antibody arrays and is provided with a 16 well gasket to allow separate samples to be applied to each array. Each antibody is spotted in quadruplicate in each array. For reproducible quantitation, eight of the arrays are used with a cocktail of protein standards to produce a standard curve. The same 8 standard curve arrays can be used across multiple slides, allowing measurement of 22 experimental samples with 2 slides, 36 with 3 slides etc. For high through-put, 4 slides can be nested into a tray matching a standard microplate, allowing automated processing with a liquid handling workstation. Array processing can be completed within one working day (see workflow diagram below) and arrays can be analyzed with a wide number of laser glass slide array / gene microarray scanners. If you don't have a suitable scanner then we recommend our membrane antibody arrays, which can be analyzed with any WB chemiluminescent reader. The standard is affinity purified. "

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规格

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性能和储存信息

运输条件

Blue Ice

储存信息

-20°C

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产品实验方案

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靶点信息

Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans (PubMed : 21270403, PubMed : 32670276). Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. These ligands accumulate at inflammatory sites during the pathogenesis of various diseases, including diabetes, vascular complications, neurodegenerative disorders, and cancers and RAGE transduces their binding into pro-inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction or inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons (PubMed : 19901339). ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability (By similarity). Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome (By similarity). Promotes also extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (By similarity).. Isoform 2. Is able to advanced glycosylation end product (AGE)-induce nuclear factor NF-kappa-B activation.. Isoform 10. Down-regulates receptor for advanced glycosylation end products (RAGE)-ligand induced signaling through various MAPK pathways including ERK1/2, p38 and SAPK/JNK. Significantly affects tumor cell properties through decreasing cell migration, invasion, adhesion and proliferation, and increasing cellular apoptosis. Exhibits drastic inhibition on tumorigenesis in vitro.

See full target information Ager

其他靶点

Csf2rb,,,,,,,,,,,,,,,,,Il1rl1,,,,,,H60a,,,,,,,,Il17a,Lepr,,,,,,,,,,,,,,,,,,,,,,,,,,,,Il7r,,Ccl17,,,,,,,,,,,,,,Il1rl1,,,,,,H60a,,,,,,,,Il17a,Lepr,,,,,,,,,,,,,,,,,,,,,,,,,,,,Il7r,,Ccl17,Ahsg,Areg,Axl,Btc,C5,Ccl11,Ccl19,Ccl20,Ccl22,Ccl24,Ccl5,Ccl6,Cd27,Cd40lg,T-cell differentiation antigen CD6,CD70,Cd80,Clu,Csf1,Csf3,Ctf1,Cx3cl1,Cxcl1,Cxcl11,Cxcl12,Cxcl13,Cxcl2,Cxcl5,Cxcl9,Dcn,Dll4,Eng,Endothelial cell-specific molecule 1,Faslg,Fcgr2,Fgf2,Flt3lg,Flt4,Gas1,Gpnmb,Grn,Icam1,Ifna11,Ifng,Ifnl2,Igf1,Igfbp2,Igfbp3,Igfbp5,Il12a,Il12b,Il13,Il17f,IL1A_MOUSE,Il1b,Il1rn,Il20,Il23a,IL-25,Il3,Il33,Il4,Il5,Il6,Il7,Il9,Kitlg,Lep,Mbl2,Ccn3,Olr1,Pf4,Pgf,Postn,Prl,,Ptx3,Retn,Sele,Selp,Spint1,Thpo,Tnfrsf13c,Tnfrsf1a,Tnfrsf8,Tnfrsf9,Tnfsf10,Tnfsf12,Tnfsf18,Tnfsf4,Tnfsf8,Tslp,Vcam1,Vegfa,Xcl1

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小鼠Cytokine抗体阵列(160 Targets) - Quantitative

Mouse Cytokine Antibody Array (160 Targets) - Quantitative

关键信息

检测类型

反应种属

靶标

检测方法

检测平台

样品类型

产品详情