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AB197446

人IGF Signaling抗体阵列(10 Targets) - Quantitative

Human IGF Signaling Antibody Array (10 Targets) - Quantitative

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(1 Publication)

ab197446 can be used for quantitative measurement of 10 Human cytokines.

查看别名

IBP1, IGF-1, IGF1, Insulin-like growth factor 1, Insulin-like growth factor I, Mechano growth factor, Somatomedin-C, IGF-I, MGF, BP2, IBP2, IGFBP2, Insulin-like growth factor-binding protein 2, IBP-2, IGF-binding protein 2, IGFBP-2, CD221, Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, IGF-I receptor, IGF1R, IBP4, IGFBP4, Insulin-like growth factor-binding protein 4, IBP-4, IGF-binding protein 4, IGFBP-4, Insulin, INS, IBP1, IGFBP1, Insulin-like growth factor-binding protein 1, IBP-1, IGF-binding protein 1, IGFBP-1, Placental protein 12, PP12, IBP3, IGFBP3, Insulin-like growth factor-binding protein 3, IBP-3, IGF-binding protein 3, IGFBP-3, IGF-2, PP1446, IGF2, Insulin-like growth factor 2, Insulin-like growth factor II, Somatomedin-A, T3M-11-derived growth factor, IGF-II, CD222, MPRI, IGF2R, Cation-independent mannose-6-phosphate receptor, CI Man-6-P receptor, CI-MPR, M6PR, 300 kDa mannose 6-phosphate receptor, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, M6P/IGF2 receptor, MPR 300, IGF-II receptor, M6P/IGF2R, IBP6, IGFBP6, Insulin-like growth factor-binding protein 6, IBP-6, IGF-binding protein 6, IGFBP-6

3 Images
Multiplex Protein Detection - Human IGF Signaling Antibody Array (10 Targets) - Quantitative (AB197446)
  • Multiplex Protein Detection

Supplier Data

Multiplex Protein Detection - Human IGF Signaling Antibody Array (10 Targets) - Quantitative (AB197446)

Array map for Abcam Human IGF Signaling Antibody Array (10 Targets) - Quantitative (ab197446).

Multiplex Protein Detection - Human IGF Signaling Antibody Array (10 Targets) - Quantitative (AB197446)
  • Multiplex Protein Detection

Supplier Data

Multiplex Protein Detection - Human IGF Signaling Antibody Array (10 Targets) - Quantitative (AB197446)

Standard curve obtained using Abcam Human IGF Signaling Antibody Array (10 Targets) - Quantitative (ab197446).

Multiplex Protein Detection - Human IGF Signaling Antibody Array (10 Targets) - Quantitative (AB197446)
  • Multiplex Protein Detection

Supplier Data

Multiplex Protein Detection - Human IGF Signaling Antibody Array (10 Targets) - Quantitative (AB197446)

Assay summary for Abcam Human IGF Signaling Antibody Array (10 Targets) - Quantitative (ab197446).

关键信息

反应种属

Human

靶标

IGF1

target

检测方法

Fluorescent

检测平台

Multiplex

样品类型

Tissue Lysate, Plasma, Cell culture media, Serum, Other biological fluids, Cell Lysate

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搭配使用产品

Reagents, Controls & Accessories

AB270055

Protease Inhibitor Cocktail EDTA Free (100X)

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Assay Kits

AB211651

Human IGF1 ELISA Kit

SimpleStep

ELISA - Human IGF1 ELISA Kit (AB211651)

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  • 0
Multiplex Kits

AB133999

Mouse Inflammation Antibody Array - Membrane (40 Targets)

Multiplex Protein Detection - Mouse Inflammation Antibody Array - Membrane (40 Targets) (AB133999)

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Primary Antibodies

AB182408

Anti-IGF1 Receptor antibody [EPR19322]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry - Anti-IGF1 Receptor antibody [EPR19322] (AB182408)

  • 4
  • 2
Primary Antibodies

AB308214

Anti-IGF2 antibody [HL1982]

Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-IGF2 antibody [HL1982] (AB308214)

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产品详情

ab197446 can be used for quantitative measurement of 10 Human cytokines. Suitable for serum, plasma, cell culture media, other body fluids, cell and tissue lysates.

Targets names: IGF-1, IGF-2, Insulin, IGF-1R, IGF-2R, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-6.

Quantitative antibody arrays can be used to quantitate up to 40 cytokines with as little as 50 µL of sample. Arrays are available for 400 human and 200 mouse proteins. Each glass slide is spotted with 16 identical antibody arrays and is provided with a 16 well gasket to allow separate samples to be applied to each array. Each antibody is spotted in quadruplicate in each array. For reproducible quantitation, eight of the arrays are used with a cocktail of protein standards to produce a standard curve. The same 8 standard curve arrays can be used across multiple slides, allowing measurement of 22 experimental samples with 2 slides, 36 with 3 slides etc. For high through-put, 4 slides can be nested into a tray matching a standard microplate, allowing automated processing with a liquid handling workstation. Array processing can be completed within one working day (see workflow diagram below) and arrays can be analyzed with a wide number of laser glass slide array / gene microarray scanners. If you don’t have a suitable scanner then we recommend our membrane antibody arrays, which can be analyzed with any WB chemiluminescent reader. "

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规格

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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
-20°C
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产品实验方案

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靶点信息

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed : 21076856, PubMed : 24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV : ITGB3 and ITGA6 : ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed : 19578119, PubMed : 22351760, PubMed : 23243309, PubMed : 23696648). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity).
See full target information IGF1

其他靶点

IGF1R,IGF2,IGF2R,IGFBP1,IGFBP2,IGFBP3,IGFBP4,IGFBP6,INS
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 24: PubMed34184083

2021

M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Lv,Chao Liu,Fu-Kun Chen,Zhi-Ping Feng,Li Jia,Peng-Jie Liu,Zhi-Xian Yang,Fei Hou,Zhi-Yong Deng
View all publications
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