AB197421

人Angiogenesis抗体阵列B (30 Targets)- Quantitative

Name: 人Angiogenesis抗体阵列B (30 Targets)- Quantitative (ab197421)| Abcam中文官网
Brand: Abcam Limited
SKU: AB197421
Price: 21641 CNY
Availability: InStock

Human Angiogenesis Antibody Array B (30 Targets)- Quantitative

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ab197421 can be used for quantitative measurement of 30 Human Angiogenesis proteins.

查看别名

RNASE5, ANG, Angiogenin, Ribonuclease 5, RNase 5

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Multiplex Protein Detection - Human Angiogenesis Antibody Array B (30 Targets)- Quantitative (AB197421)

Multiplex Protein Detection

Supplier Data

Multiplex Protein Detection - Human Angiogenesis Antibody Array B (30 Targets)- Quantitative (AB197421)

Array Map for Abcam Human Angiogenesis Antibody Array B (30 Targets) - Quantitative (ab197421)

Multiplex Protein Detection

Supplier Data

Multiplex Protein Detection - Human Angiogenesis Antibody Array B (30 Targets)- Quantitative (AB197421)

Standard Curves obtained from Abcam Human Angiogenesis Antibody Array B (30 Targets) - Quantitative (ab197421)

关键信息

反应种属

Human

靶标

ANG

target

检测方法

Fluorescent

检测平台

Multiplex

样品类型

Tissue Lysate, Plasma, Cell culture media, Serum, Other biological fluids, Cell Lysate

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产品详情

ab197421 can be used for quantitative measurement of 30 Human Angiogenesis proteins. Suitable for serum, plasma, cell culture media, other body fluids, cell and tissue lysates.
Targets: ANG-1, Angiostatin, CXCL16, EGF, FGF-4, Follistatin, G-CSF, GM-CSF, I-309, IL-1β, IL-4, IL-10, IL-12p40, IL-12p70, I-TAC, MCP-2, MCP-3, MCP-4, MMP-1, MMP-9, PECAM-1, TGFα, TGFβ3, Tie-1, Tie-2, uPAR, VEGF, VEGF R2, VEGF R3, VEGF-D.

Quantitative antibody arrays can be used to quantitate up to 40 cytokines with as little as 50 µL of sample. Arrays are available for 400 human and 200 mouse proteins. Each glass slide is spotted with 16 identical antibody arrays and is provided with a 16 well gasket to allow separate samples to be applied to each array. Each antibody is spotted in quadruplicate in each array. For reproducible quantitation, eight of the arrays are used with a cocktail of protein standards to produce a standard curve. The same 8 standard curve arrays can be used across multiple slides, allowing measurement of 22 experimental samples with 2 slides, 36 with 3 slides etc. For high through-put, 4 slides can be nested into a tray matching a standard microplate, allowing automated processing with a liquid handling workstation. Array processing can be completed within one working day (see workflow diagram below) and arrays can be analyzed with a wide number of laser glass slide array / gene microarray scanners. If you don’t have a suitable scanner then we recommend our membrane antibody arrays, which can be analyzed with any WB chemiluminescent reader. The standard is affinity purified. "

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规格

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性能和储存信息

运输条件

Blue Ice

储存信息

-20°C

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产品实验方案

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靶点信息

Secreted ribonuclease that can either promote or restrict cell proliferation of target cells, depending on the context (PubMed : 12051708, PubMed : 1400510, PubMed : 19332886, PubMed : 20129916, PubMed : 21855800, PubMed : 23047679, PubMed : 23843625, PubMed : 2424496, PubMed : 2459697, PubMed : 2730651, PubMed : 27518564, PubMed : 28176817, PubMed : 29100074, PubMed : 29748193, PubMed : 3122207, PubMed : 32510170, PubMed : 38718836, PubMed : 8159680, PubMed : 8570639, PubMed : 8622921, PubMed : 9578571). Endocytosed in target cells via its receptor PLXNB2 and translocates to the cytoplasm or nucleus (PubMed : 29100074, PubMed : 32510170). Under stress conditions, localizes to the cytoplasm and promotes the assembly of stress granules (SGs) : specifically cleaves a subset of tRNAs within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs), resulting in translation repression and inhibition of cell proliferation (PubMed : 1400510, PubMed : 19332886, PubMed : 20129916, PubMed : 21855800, PubMed : 23047679, PubMed : 27518564, PubMed : 29100074, PubMed : 29748193, PubMed : 32510170, PubMed : 38718836). tiRNas also prevent formation of apoptosome, thereby promoting cell survival (By similarity). Preferentially cleaves RNAs between a pyrimidine and an adenosine residue, suggesting that it cleaves the anticodon loop of tRNA(Ala) (32-UUAGCAU-38) after positions 33 and 36 (PubMed : 3289612, PubMed : 38718836). Cleaves a subset of tRNAs, including tRNA(Ala), tRNA(Glu), tRNA(Gly), tRNA(Lys), tRNA(Val), tRNA(His), tRNA(Asp) and tRNA(Sec) (PubMed : 31582561). Under growth conditions and in differentiated cells, translocates to the nucleus and stimulates ribosomal RNA (rRNA) transcription, including that containing the initiation site sequences of 45S rRNA, thereby promoting cell growth and proliferation (PubMed : 12051708, PubMed : 15735021, PubMed : 27518564, PubMed : 29100074, PubMed : 8127865). Angiogenin induces vascularization of normal and malignant tissues via its ability to promote rRNA transcription (PubMed : 19354288, PubMed : 4074709, PubMed : 8448182). Involved in hematopoietic stem and progenitor cell (HSPC) growth and survival by promoting rRNA transcription in growth conditions and inhibiting translation in response to stress, respectively (PubMed : 27518564). Mediates the crosstalk between myeloid and intestinal epithelial cells to protect the intestinal epithelial barrier integrity : secreted by myeloid cells and promotes intestinal epithelial cells proliferation and survival (PubMed : 32510170). Also mediates osteoclast-endothelial cell crosstalk in growing bone : produced by osteoclasts and protects the neighboring vascular cells against senescence by promoting rRNA transcription (By similarity).

See full target information ANG

其他靶点

PLG,CXCL16,EGF,FGF4,FST,CSF3,CSF2,CCL1,IL1B,IL10,IL12B,IL12A,IL4,CXCL11,CCL8,CCL7,CCL13,MMP1,PECAM1,Protransforming growth factor alpha,TGFB3,TIE1,TEK,PLAUR,VEGFA,VEGFD,KDR,FLT4

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人Angiogenesis抗体阵列B (30 Targets)- Quantitative

Human Angiogenesis Antibody Array B (30 Targets)- Quantitative

Multiplex Protein Detection - Human Angiogenesis Antibody Array B (30 Targets)- Quantitative (AB197421)

Multiplex Protein Detection - Human Angiogenesis Antibody Array B (30 Targets)- Quantitative (AB197421)

关键信息

反应种属

靶标

检测方法

检测平台

样品类型

产品详情