Anti-proBNP抗体[5B6] (ab13111)
Key features and details
- Mouse monoclonal [5B6] to proBNP
- Suitable for: ELISA, WB
- Reacts with: Recombinant fragment
- Isotype: IgG1
概述
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产品名称
Anti-proBNP抗体[5B6]
参阅全部 proBNP 一抗 -
描述
小鼠单克隆抗体[5B6] to proBNP -
宿主
Mouse -
经测试应用
适用于: ELISA, WBmore details -
种属反应性
与反应: Recombinant fragment -
免疫原
Synthetic peptide:
HPLGSPGSASDL
, corresponding to amino acids 1 - 12 of Human proBNP. -
常规说明
This product has switched from ascites to TCS on 10th June 2020.
Immunoglobulin concentrations vary from batch to batch (generally 4-6 mg/ml for this clone). Please contact technical services for the latest information.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.1% Sodium azide -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
5B6 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab13111于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ELISA |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration. Detects a band of approximately 13 kDa.
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说明 |
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ELISA
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. Detects a band of approximately 13 kDa. |
靶标
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功能
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. -
组织特异性
Brain and also in atria, but at much lower levels than ANP. -
序列相似性
Belongs to the natriuretic peptide family. -
细胞定位
Secreted. - Information by UniProt
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别名
- ANFB_HUMAN antibody
- BNP antibody
- BNP(1-32) antibody
see all
图片
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WB detecting proBNP showing comparable detection from a range of antibodies available. Lane 1 - ab13111 [5B6], lane 2 - ab13115 [15F11], lane 3 - ab13059 [11D1], lane 4 - ab13124 [15D7], lane 5 - ab13122 [13C1], lane 6 ab13123 [24E11]. WB detecting proBNP showing comparable detection from a range of antibodies available. Lane 1 - ab13111 [5B6], lane 2 - ab13115 [15F11], lane 3 - ab13059 [11D1], lane 4 - ab13124 [15D7], lane 5 - ab13122 [13C1], lane 6 ab13123 [24E11].
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab13111 被引用在 4 文献中.
- Hsu A et al. Targeting transcription in heart failure via CDK7/12/13 inhibition. Nat Commun 13:4345 (2022). PubMed: 35896549
- Hsu A et al. Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling. J Clin Invest 130:2966-2977 (2020). PubMed: 32106109
- Duan Q et al. BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure. Sci Transl Med 9:N/A (2017). PubMed: 28515341
- Carlson C et al. Phenotypic Screening with Human iPS Cell-Derived Cardiomyocytes: HTS-Compatible Assays for Interrogating Cardiac Hypertrophy. J Biomol Screen N/A:N/A (2013). PubMed: 24071917