All tags Cancer c-Myc 与癌症:个体化治疗之外的另一选择

c-Myc 与癌症:个体化治疗之外的另一选择

Gerard Evan 教授将向我们解释为什么他认为靶向癌症的驱动力可能比个体化治疗更有效。

Gerard Evan 教授的主要贡献讲座中包括了:Myc 参与细胞凋亡的发现过程,以及研究 Myc 的早期工具的发展,例如抗 Myc 标签的 9E10 抗体。





Evan 教授接着谈论了 像Myc 和 Ras 等癌症形成因素的中的 T 细胞排除,是他实验室当前的研究重点。 


Wistia video thumbnail - c-Myc and cancer: an alternative to personalized medicine?

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  • Evan, G. I. et al.(1985).Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.Molecular and Cellular Biology 5, 3610–3616
  • Evan, G. I. et al.(1992).Induction of apoptosis in fibroblasts by c-myc protein.Cell 69, 119–128
  • Sodir, N.M. et al.(2011).Endogenous Myc maintains the tumor micro-environment.Genes Dev 25, 907–916
  • Annibali, D. et al.(2014).Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis.Nature communications 5, 4632
  • Kress, T.R. et al.(2016).Identification of MYC-dependent transcriptional programs in oncogene-addicted liver tumors.Cancer Res 76, 3463–3472