Key features and details
- Rabbit polyclonal to PKC gamma
- Reacts with: Human
- Isotype: IgG
参阅全部 PKC gamma 一抗
描述兔多克隆抗体to PKC gamma
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
存储溶液Preservative: 0.05% Sodium azide
Concentration information loading...
Immunohistochemistry: 1/250 (using horseradish peroxidase or alkaline phosphatase).
Western blot (using horseradish peroxidase or alkaline phosphatase): 1/250. Predicted molecular weight: 84 kDa.
Not tested in other applications.
Optimal dilutions / concentrations should be determined by the end user.
With a more sensitive detection system, such as enhanced chemiluminescence or ELISA, the antibody may be diluted further.
It has also been reported to be useful for immunoprecipitation of PKC gamma.
功能This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
组织特异性Expressed in Purkinje cells of the cerebellar cortex.
疾病相关Defects in PRKCG are the cause of spinocerebellar ataxia type 14 (SCA14) [MIM:605361]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA14 is an autosomal dominant cerebellar ataxia (ADCA).
序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 C2 domain.
Contains 2 phorbol-ester/DAG-type zinc fingers.
Contains 1 protein kinase domain.
- Information by UniProt
- KPCG_HUMAN antibody
- MGC57564 antibody
- OTTHUMP00000067291 antibody