Key features and details
- Rabbit polyclonal to Phosphoserine Aminotransferase
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
参阅全部 Phosphoserine Aminotransferase 一抗
描述兔多克隆抗体to Phosphoserine Aminotransferase
经测试应用适用于: WB, ICC/IFmore details
预测可用于: Mouse, Rat, Rabbit, Cow
Recombinant protein fragment with a sequence corresponding to a region within amino acids 48 and 298 of Human Phosphoserine Aminotransferase (NP_478059).
- 293T, A431, H1299, HeLa, HepG2, Molt-4 and Raji cell lines. H1299 whole cell lysate for WB and A549 cells for IF.
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存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.025% Proclin 300
Constituents: 78% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine)
Concentration information loading...
纯度Immunogen affinity purified
功能Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
组织特异性Expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon.
通路Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.
Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.
疾病相关Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD) [MIM:610992]. PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.
序列相似性Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
- Information by UniProt
- EC 184.108.40.206 antibody
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ab96136 被引用在 13 文献中.
- Tajan M et al. Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Nat Commun 12:366 (2021). PubMed: 33446657
- Spillier Q et al. Structure-Activity Relationships (SARs) of a-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH). Pharmaceuticals (Basel) 13:N/A (2020). PubMed: 31979167
- Duan W & Liu X PSAT1 Upregulation Contributes to Cell Growth and Cisplatin Resistance in Cervical Cancer Cells via Regulating PI3K/AKT Signaling Pathway. Ann Clin Lab Sci 50:512-518 (2020). PubMed: 32826249
- Dewdney B et al. The effects of fructose and metabolic inhibition on hepatocellular carcinoma. Sci Rep 10:16769 (2020). PubMed: 33028928
- Zhao R et al. LncRNA BC200 Promotes Esophageal Squamous Cell Cancer Migration and Invasion and Can Regulate ATF4 Expression. Front Oncol 10:1392 (2020). PubMed: 32974142