PE Anti-Lambda Light chain抗体[GA170] (ab1198)
Key features and details
- PE Mouse monoclonal [GA170] to Lambda Light chain
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG2a
概述
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产品名称
PE Anti-Lambda Light chain抗体[GA170]
参阅全部 Lambda Light chain 一抗 -
描述
PE小鼠单克隆抗体[GA170] to Lambda Light chain -
宿主
Mouse -
偶联物
PE. Ex: 488nm, Em: 575nm -
特异性
This antibody reacts with lambda light chains of human immunoglobulins. -
种属反应性
与反应: Human -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
Preservative: 0.1% Sodium azide
Constituent: 0.5% BSA -
Concentration information loading... -
克隆
单克隆 -
克隆编号
GA170 -
骨髓瘤
unknown -
同种型
IgG2a -
轻链类型
unknown -
研究领域
相关产品
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Isotype control
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Recombinant Protein
应用
应用说明
Measurement of lambda light chain in human lysed whole peripheral blood or mononuclear cells separated by density gradient.
Studies of clonality of B cell lymphomas in tissue.
Studies of clonality of B cell leukemias in peripheral blood.
Lambda (PE) immunofluorescence analysis can be performed on a flow cytometerequipped with an excitation source of 488nm and fitted with logarithmic amplifiers.
10µl ofLambda (PE) is sufficient for labelling of 1x106 cells.
Studies of clonality of B cell lymphomas in tissue.
Studies of clonality of B cell leukemias in peripheral blood.
Lambda (PE) immunofluorescence analysis can be performed on a flow cytometerequipped with an excitation source of 488nm and fitted with logarithmic amplifiers.
10µl ofLambda (PE) is sufficient for labelling of 1x106 cells.
靶标
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相关性
All five immunoglobulin classes share the same basic four polypeptide chain structure of two heavy-chains and two light chains. There are five heavy chain types, and two light-chain types (Kappa and Lambda) both having a molecular weight of 22.5kDa. Any heavy-chain type can associate with either light-chain type, but on any immunoglobulin molecule both light-chains are of the same type. Kappa and Lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of Kappa to Lambda is 70:30 , the vast majority of which is bound to heavy-chain in immunoglobulin. In normal individuals low levels of free light-chain arepresent in serum (kappa, 1.6-15.2 mg/L; Lambda, 0.4-4.2mg/L), with the occurrence of multiple myeloma or other B-cell malignancies these levels can be greatly elevated and can be found at high levels in the urine (Bence-Jones proteins). -
细胞定位
Cytoplasmic -
数据库链接
- Entrez Gene: 3535 Human
- Entrez Gene: 3546 Human
- Entrez Gene: 8217 Human
- Omim: 147220 Human
- SwissProt: P01701 Human
- SwissProt: P01842 Human
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别名
- Bence Jones protein antibody
- BJP antibody
- Constant region of lambda light chains antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (0)
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