PE Anti-CD13抗体[WM15],prediluted (ab69775)
Key features and details
- PE Mouse monoclonal [WM15] to CD13, prediluted
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG1
概述
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产品名称
PE Anti-CD13抗体[WM15],prediluted
参阅全部 CD13 一抗 -
描述
PE小鼠单克隆抗体[WM15] to CD13,prediluted -
宿主
Mouse -
偶联物
PE. Ex: 488nm, Em: 575nm -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human
预测可用于: Non human primates -
免疫原
Tissue, cells or virus corresponding to Human CD13. Human AML cells
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常规说明
The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 0.2% BSA, PBS -
Concentration information loading...
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纯度
Size exclusion -
克隆
单克隆 -
克隆编号
WM15 -
同种型
IgG1 -
研究领域
相关产品
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Alternative Versions
- Biotin Anti-CD13 antibody [WM15] (ab130430)
- PerCP/Cy5.5® Anti-CD13 antibody [WM15] (ab157316)
- Alexa Fluor® 488 Anti-CD13 antibody [WM15] (ab239271)
- APC Anti-CD13 antibody [WM15] (ab239295)
- PE/DyLight™ 594 Anti-CD13 antibody [WM15] (ab239330)
- Anti-CD13 antibody [WM15] - BSA and Azide free (ab252261)
- FITC Anti-CD13 antibody [WM15] (ab52461)
- Anti-CD13 antibody [WM15] (ab7417)
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab69775于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
Flow Cyt |
Use at an assay dependent concentration.
or 100 ul of whole blood. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
说明 |
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Flow Cyt
Use at an assay dependent concentration. or 100 ul of whole blood. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. -
组织特异性
Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients. -
序列相似性
Belongs to the peptidase M1 family. -
结构域
Amino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies). -
翻译后修饰
Sulfated.
N- and O-glycosylated.
May undergo proteolysis and give rise to a soluble form. -
细胞定位
Cell membrane. Cytoplasm > cytosol. A soluble form has also been detected. - Information by UniProt
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数据库链接
- Entrez Gene: 290 Human
- Omim: 151530 Human
- SwissProt: P15144 Human
- Unigene: 1239 Human
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别名
- Alanyl (membrane) aminopeptidase antibody
- Alanyl aminopeptidase antibody
- Aminopeptidase M antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab69775 被引用在 5 文献中.
- Kessler T et al. Aminopeptidase N (CD13): Expression, Prognostic Impact, and Use as Therapeutic Target for Tissue Factor Induced Tumor Vascular Infarction in Soft Tissue Sarcoma. Transl Oncol 11:1271-1282 (2018). PubMed: 30125801
- Schmidt LH et al. Potential therapeutic impact of CD13 expression in non-small cell lung cancer. PLoS One 12:e0177146 (2017). Flow Cyt ; Human . PubMed: 28604784
- Favaloro EJ et al. CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated. Exp Hematol 21:1695-701 (1993). PubMed: 7902291
- Bradstock KF et al. Human myeloid differentiation antigens identified by monoclonal antibodies: expression on leukemic cells. Pathology 17:392-9 (1985). PubMed: 3865147
- Bradstock KF et al. Myeloid progenitor surface antigen identified by monoclonal antibody. Br J Haematol 61:11-20 (1985). PubMed: 4052321