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Signal Transduction Second Messenger Nucleotide Messenger cAMP

Anti-PDE6 gamma抗体(ab5664)

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Western blot - Anti-PDE6 gamma antibody (ab5664)

    Key features and details

    • Rabbit polyclonal to PDE6 gamma
    • Suitable for: WB
    • Reacts with: Mouse, Rat, Sheep, Cow, Human
    • Isotype: IgG

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    概述

    • 产品名称

      Anti-PDE6 gamma抗体
    • 描述

      兔多克隆抗体to PDE6 gamma
    • 宿主

      Rabbit
    • 经测试应用

      适用于: WBmore details
    • 种属反应性

      与反应: Mouse, Rat, Sheep, Cow, Human
      预测可用于: Guinea pig, Cat, Dog
    • 免疫原

      Synthetic peptide corresponding to Cow PDE6 gamma aa 1-15.
      Sequence:

      MNLEPPKAEIRSATR


      (Peptide available as ab5864)
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • 常规说明

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    性能

    • 形式

      Liquid
    • 存放说明

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
    • 存储溶液

      Preservative: 0.05% Sodium azide
      Constituents: 99% PBS, 0.1% BSA
    • Concentration information loading...
    • 纯度

      Ammonium Sulphate Precipitation
    • 纯化说明

      Concentration: not determined.
    • Primary antibody说明

      The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways, such as insulin secretion, platelet aggregation, smooth muscle relaxation, olfaction, and vision. Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates. While mammalian PDEs are divided into major families based on their substrate specificities, kinetic properties, allosteric regulators, inhibitor sensitivities, and amino acid sequences, each family and even members within a family display distinct tissue, cell, and subcellular expression patters. This suggests that individual PDE family members are involved in discrete signal transduction pathways. PDE6 is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. There are five different subunits consisting of rod and cone specific catalytic subunits: alpha’ (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family). The catalytic core of the PDE6 system is comprised of alpha’/alpha’ homodimers in the cone and alpha/beta heterodimers in the rod. The C-terminus of both the catalytic and inhibitory subunits is modified by methylation, myristyolation and prenylation which have been shown to be critical for proper complex assembly and membrane association.
    • 克隆

      多克隆
    • 同种型

      IgG
    • 研究领域

      • Signal Transduction
      • Second Messenger
      • Nucleotide Messenger
      • cAMP
      • Signal Transduction
      • Second Messenger
      • Nucleotide Messenger
      • cGMP

    相关产品

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Immunizing Peptide (Blocking)

      • PDE6 gamma peptide (ab5864)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

    应用

    Our Abpromise guarantee covers the use of ab5664 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    应用 Ab评论 说明
    WB 1/500. Detects a band of approximately 10 kDa.Can be blocked with PDE6 gamma peptide (ab5864).

    靶标

    • 功能

      Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
    • 疾病相关

      Defects in PDE6G are the cause of retinitis pigmentosa type 57 (RP57) [MIM:613582]. RP57 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
    • 序列相似性

      Belongs to the rod/cone cGMP-PDE gamma subunit family.
    • Target information above from: UniProt accession P18545 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • 数据库链接

      • Entrez Gene: 281977 Cow
      • Entrez Gene: 5148 Human
      • Entrez Gene: 18588 Mouse
      • Entrez Gene: 114248 Rat
      • Omim: 180073 Human
      • SwissProt: P04972 Cow
      • SwissProt: P54827 Dog
      • SwissProt: Q9EQQ8 Guinea pig
      • SwissProt: P18545 Human
      • SwissProt: P09174 Mouse
      • Unigene: 654482 Human
      • Unigene: 39200 Mouse
      • Unigene: 21249 Rat
      see all
    • 别名

      • 5''-cyclic phosphodiesterase subunit gamma antibody
      • CNRG_HUMAN antibody
      • GMP-PDE gamma antibody
      • MGC125749 antibody
      • PDE 6 antibody
      • PDE6G antibody
      • PDEG antibody
      • Phosphodiesterase 6G cGMP Specific antibody
      • Phosphodiesterase 6G cGMP specific rog gamma antibody
      • Retinal Rod Photoreceptor cGMP Phosphodiesterase gamma antibody
      • Retinal rod rhodopsin sensitive cGMP 3' 5'vcyclic phosphodiesterase subunit gamma antibody
      • Retinal rod rhodopsin-sensitive cGMP 3'' antibody
      • Rod cG PDE G antibody
      • RP57 antibody
      see all

    图片

    • Western blot - Anti-PDE6 gamma antibody (ab5664)
      Western blot - Anti-PDE6 gamma antibody (ab5664)

      Western blot of PDE6 gamma on sheep retinal extracts using ab5664.

    实验方案

    • Western blot protocols
    • Immunohistochemistry protocols

    Click here to view the general protocols

    数据表及文件

    • Datasheet
  • 文献 (0)

    发表研究结果有使用 ab5664?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab5664 尚未被引用在任何文献中。

    客户评价及客户问答

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    There are currently no Customer reviews or Questions for ab5664.
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