Anti-PDE6 alpha抗体(ab5660)
Key features and details
- Rabbit polyclonal to PDE6 alpha
- Suitable for: WB
- Reacts with: Sheep, Cow
- Isotype: IgG
概述
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产品名称
Anti-PDE6 alpha抗体
参阅全部 PDE6 alpha 一抗 -
描述
兔多克隆抗体to PDE6 alpha -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Sheep, Cow
预测可用于: Mouse, Chicken, Human -
免疫原
Synthetic peptide corresponding to Human PDE6C aa 16-29.
Sequence:MPQFAKEYFDRKLR
(Peptide available asab5863) -
阳性对照
- WB: sheep retinal extract.
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常规说明
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA -
Concentration information loading...
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纯度
Ammonium Sulphate Precipitation -
纯化说明
Concentration: not determined. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
Our Abpromise guarantee covers the use of ab5660 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用 | Ab评论 | 说明 |
---|---|---|
WB | 1/500. Detects a band of approximately 90 kDa. |
靶标
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功能
This protein participates in processes of transmission and amplification of the visual signal. -
疾病相关
Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. -
序列相似性
Belongs to the cyclic nucleotide phosphodiesterase family.
Contains 2 GAF domains. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 281973 Cow
- Entrez Gene: 5145 Human
- Entrez Gene: 225600 Mouse
- Omim: 180071 Human
- SwissProt: P11541 Cow
- SwissProt: P16499 Human
- SwissProt: P27664 Mouse
- Unigene: 151710 Human
see all -
别名
- 5''-cyclic phosphodiesterase subunit alpha antibody
- CGPR A antibody
- GMP PDE alpha antibody
see all
图片
数据表及文件
文献 (1)
ab5660 被引用在 1 文献中.
- Iribarne M et al. Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Sci Rep 7:45962 (2017). WB ; Zebrafish . PubMed: 28378769