Anti-PDE6 alpha抗体(ab5660)

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Western blot - Anti-PDE6 alpha antibody (ab5660)

    Key features and details

    • Rabbit polyclonal to PDE6 alpha
    • Suitable for: WB
    • Reacts with: Sheep, Cow
    • Isotype: IgG

    概述

    • 产品名称

      Anti-PDE6 alpha抗体
      参阅全部 PDE6 alpha 一抗

    • 描述

      兔多克隆抗体to PDE6 alpha

    • 宿主

      Rabbit

    • 经测试应用

      适用于: WBmore details

    • 种属反应性

      与反应: Sheep, Cow
      预测可用于: Mouse, Chicken, Human

    • 免疫原

      Synthetic peptide corresponding to Human PDE6C aa 16-29.
      Sequence:

      MPQFAKEYFDRKLR


      (Peptide available as ab5863)
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • 阳性对照

      • WB: sheep retinal extract.

    • 常规说明

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    性能

    应用

    Our Abpromise guarantee covers the use of ab5660 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    应用 Ab评论 说明
    WB 1/500. Detects a band of approximately 90 kDa.

    靶标

    • 功能

      This protein participates in processes of transmission and amplification of the visual signal.

    • 疾病相关

      Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

    • 序列相似性

      Belongs to the cyclic nucleotide phosphodiesterase family.
      Contains 2 GAF domains.

    • 细胞定位

      Cell membrane.
    • Information by UniProt

    • 数据库链接

      see all

    • 别名

      • 5''-cyclic phosphodiesterase subunit alpha antibody
      • CGPR A antibody
      • GMP PDE alpha antibody
      • GMP-PDE alpha antibody
      • PDE 6 alpha antibody
      • PDE 6A antibody
      • PDE V B1 antibody
      • PDE V-B1 antibody
      • PDE6A antibody
      • PDE6A_HUMAN antibody
      • PDEA antibody
      • Phosphodiesterase 6 alpha antibody
      • Phosphodiesterase 6A alpha subunit antibody
      • Phosphodiesterase 6A antibody
      • Phosphodiesterase 6A cGMP specific rod alpha antibody
      • Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha antibody
      • Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit antibody
      • Rod cGMP-specific 3'' antibody
      see all

    图片

    • Western blot - Anti-PDE6 alpha antibody (ab5660)
      Western blot - Anti-PDE6 alpha antibody (ab5660)

      Western blot of PDE6C on sheep retinal extracts using ab5660.

    文献 (1)

    发表研究结果有使用 ab5660？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab5660 被引用在 1 文献中.

    • Iribarne M  et al. Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Sci Rep 7:45962 (2017). WB ; Zebrafish . PubMed: 28378769

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