Anti-PAX7抗体[PAX7497] (ab199010)
Key features and details
- Mouse monoclonal [PAX7497] to PAX7
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-PAX7抗体[PAX7497]
参阅全部 PAX7 一抗 -
描述
小鼠单克隆抗体[PAX7497] to PAX7 -
宿主
Mouse -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein corresponding to Human PAX7 aa 1 to the C-terminus.
Database link: P23759 -
阳性对照
- HeLa, Jurkat, A431, MCF-7, U2OS and NIH/3T3 cells. Stomach or rhabdomyosarcoma.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.2
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA -
Concentration information loading...
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纯度
Protein A/G purified -
克隆
单克隆 -
克隆编号
PAX7497 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab199010于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (1) |
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 57 kDa.
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说明 |
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WB
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 57 kDa. |
靶标
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功能
Probable transcription factor. May have a role in myogenesis. -
疾病相关
Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2) [MIM:268220]. It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator. -
序列相似性
Belongs to the paired homeobox family.
Contains 1 homeobox DNA-binding domain.
Contains 1 paired domain. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 5081 Human
- Omim: 167410 Human
- SwissProt: P23759 Human
- Unigene: 113253 Human
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别名
- FLJ37460 antibody
- HUP1 antibody
- OTTHUMP00000002534 antibody
see all
实验方案
数据表及文件
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Datasheet download
文献 (13)
ab199010 被引用在 13 文献中.
- Cefis M et al. Endothelial cells are an important source of BDNF in rat skeletal muscle. Sci Rep 12:311 (2022). PubMed: 35013359
- Vicario N et al. Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing. Cell Death Dis 12:625 (2021). PubMed: 34135312
- Grunow B et al. Histological and biochemical evaluation of skeletal muscle in the two salmonid species Coregonus maraena and Oncorhynchus mykiss. PLoS One 16:e0255062 (2021). PubMed: 34383783
- Shang GK et al. Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRa+ mesenchymal progenitors. J Cachexia Sarcopenia Muscle N/A:N/A (2021). PubMed: 34435457
- Ling X et al. Lidocaine Inhibits Myoblast Cell Migration and Myogenic Differentiation Through Activation of the Notch Pathway. Drug Des Devel Ther 15:927-936 (2021). PubMed: 33688167