为了使您在Abcam官网的浏览体验更顺畅，请使用最新版本的浏览器比如 Google Chrome
This pathway poster includes:
Apoptosis – an overview
Apoptosis, or programmed cell death, is important in development, aging, and disease. It is triggered via extrinsic or intrinsic pathways; the extrinsic pathway involves ligand binding to death receptors, whereas the intrinsic pathway activates in response to DNA damage, ischemia or oxidative stress. Activity of the intrinsic or extrinsic pathway leads to caspase activation. Caspases then cleave cytoskeletal proteins and nuclear lamins and promote DNA degradation. Finally, apoptotic cells undergo phagocytosis.