Anti-PARL抗体(ab118554)
Key features and details
- Rabbit polyclonal to PARL
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-PARL抗体 -
描述
兔多克隆抗体to PARL -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat -
免疫原
Synthetic peptide containing 15 amino acids from the N-terminal region of Human PARL (NP_061092.3).
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阳性对照
- Human pancreas tissue; 3T3 cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab118554于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 42 kDa.
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IHC-P |
Use a concentration of 5 µg/ml.
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说明 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 42 kDa. |
IHC-P
Use a concentration of 5 µg/ml. |
靶标
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功能
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. -
序列相似性
Belongs to the peptidase S54 family. -
翻译后修饰
P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated. -
细胞定位
Mitochondrion inner membrane and Nucleus. Translocated into the nucleus by an unknown mechanism. - Information by UniProt
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数据库链接
- Entrez Gene: 55486 Human
- Entrez Gene: 381038 Mouse
- Entrez Gene: 287979 Rat
- Omim: 607858 Human
- SwissProt: Q9H300 Human
- SwissProt: Q5XJY4 Mouse
- SwissProt: Q3B8P0 Rat
- Unigene: 478469 Human
see all -
别名
- Mitochondrial intramembrane cleaving protease PARL antibody
- Mitochondrial intramembrane-cleaving protease PARL antibody
- P-beta antibody
see all
图片
数据表及文件
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Datasheet download
文献 (0)
ab118554 尚未被引用在任何文献中。