Anti-PACRG抗体(ab4090)

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Western blot - Anti-PACRG antibody (ab4090)

    Key features and details

    • Rabbit polyclonal to PACRG
    • Suitable for: WB
    • Reacts with: Mouse
    • Isotype: IgG

    概述

    • 产品名称

      Anti-PACRG抗体
      参阅全部 PACRG 一抗

    • 描述

      兔多克隆抗体to PACRG

    • 宿主

      Rabbit

    • 经测试应用

      适用于: WBmore details

    • 种属反应性

      与反应: Mouse
      预测可用于: Rat, Chicken, Zebrafish

    • 免疫原

      Synthetic peptide:

      CNVNSGDGIDYSQ

      , corresponding to amino acids 188 - 199 of Human PACRG.
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab4090于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    WB
    1/500 - 1/3000. Detects a band of approximately 40 kDa (predicted molecular weight: 33 kDa).
    说明
    WB
    1/500 - 1/3000. Detects a band of approximately 40 kDa (predicted molecular weight: 33 kDa).

    靶标

    • 功能

      Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.

    • 组织特异性

      Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.
    • Information by UniProt

    • 数据库链接

      • 别名

        • FLJ32724 antibody
        • GLUP antibody
        • HAK005771 antibody
        • Molecular chaperone/chaperonin binding protein antibody
        • Molecular chaperone/chaperonin-binding protein antibody
        • PACRG antibody
        • PACRG_HUMAN antibody
        • PARK 2 co regulated antibody
        • PARK 2 coregulated antibody
        • PARK2 co regulated antibody
        • PARK2 coregulated antibody
        • PARK2 coregulated gene protein antibody
        • PARK2CRG antibody
        • Parkin co regulated gene antibody
        • Parkin co regulated gene protein antibody
        • Parkin coregulated gene antibody
        • Parkin coregulated gene protein antibody
        • RP3 495O10.2 antibody
        see all

      图片

      • Western blot - Anti-PACRG antibody (ab4090)
        Western blot - Anti-PACRG antibody (ab4090)
        All lanes : Anti-PACRG antibody (ab4090) at 1/1500 dilution

        Lane 1 : Mouse embryonic fibroblast (MEF) whole cell lysate
        Lane 2 : Mouse embryonic fibroblast (MEF) whole cell lysate with immunising peptide

        Lysates/proteins at 35 µg per lane.

        Secondary
        All lanes : IRDye 800 conjugated Goat anti-Rabbit IgG [H&L] at 1/10000 dilution

        Predicted band size: 33 kDa
        Observed band size: 40 kDa why is the actual band size different from the predicted?

      文献 (1)

      发表研究结果有使用 ab4090？请让我们知道，以便我们可以引用本数据表中的参考文章。

      ab4090 被引用在 1 文献中.

      • Gavino C & Richard S Patched1 haploinsufficiency impairs ependymal cilia function of the quaking viable mice, leading to fatal hydrocephalus. Mol Cell Neurosci 47:100-7 (2011). PubMed: 21447392

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