Anti-PACRG抗体(ab4090)

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Western blot - Anti-PACRG antibody (ab4090)

    Key features and details

    • Rabbit polyclonal to PACRG
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    概述

    • 产品名称

      Anti-PACRG抗体
      参阅全部 PACRG 一抗

    • 描述

      兔多克隆抗体to PACRG

    • 宿主

      Rabbit

    • 经测试应用

      适用于: WBmore details

    • 种属反应性

      与反应: Human
      预测可用于: Mouse, Rat, Chicken, Zebrafish

    • 免疫原

      Synthetic peptide:

      CNVNSGDGIDYSQ

      , corresponding to amino acids 188 - 199 of Human PACRG.
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • 常规说明

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    性能

    应用

    Our Abpromise guarantee covers the use of ab4090 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    应用 Ab评论 说明
    WB 1/500 - 1/3000. Detects a band of approximately 40 kDa (predicted molecular weight: 33 kDa).

    靶标

    • 功能

      Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.

    • 组织特异性

      Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.
    • Information by UniProt

    • 数据库链接

      see all

    • 别名

      • FLJ32724 antibody
      • GLUP antibody
      • HAK005771 antibody
      • Molecular chaperone/chaperonin binding protein antibody
      • Molecular chaperone/chaperonin-binding protein antibody
      • PACRG antibody
      • PACRG_HUMAN antibody
      • PARK 2 co regulated antibody
      • PARK 2 coregulated antibody
      • PARK2 co regulated antibody
      • PARK2 coregulated antibody
      • PARK2 coregulated gene protein antibody
      • PARK2CRG antibody
      • Parkin co regulated gene antibody
      • Parkin co regulated gene protein antibody
      • Parkin coregulated gene antibody
      • Parkin coregulated gene protein antibody
      • RP3 495O10.2 antibody
      see all

    图片

    • Western blot - Anti-PACRG antibody (ab4090)
      Western blot - Anti-PACRG antibody (ab4090)
      All lanes : Anti-PACRG antibody (ab4090) at 1/1500 dilution

      Lane 1 : Mouse embryonic fibroblast (MEF) whole cell lysate
      Lane 2 : Mouse embryonic fibroblast (MEF) whole cell lysate with immunising peptide

      Lysates/proteins at 35 µg per lane.

      Secondary
      All lanes : IRDye 800 conjugated Goat anti-Rabbit IgG [H&L] at 1/10000 dilution

      Predicted band size: 33 kDa
      Observed band size: 40 kDa
      why is the actual band size different from the predicted?

    文献 (1)

    发表研究结果有使用 ab4090？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab4090 被引用在 1 文献中.

    • Gavino C & Richard S Patched1 haploinsufficiency impairs ependymal cilia function of the quaking viable mice, leading to fatal hydrocephalus. Mol Cell Neurosci 47:100-7 (2011). PubMed: 21447392

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