Anti-PACRG抗体(ab4090)
Key features and details
- Rabbit polyclonal to PACRG
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-PACRG抗体
参阅全部 PACRG 一抗 -
描述
兔多克隆抗体to PACRG -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse
预测可用于: Rat, Chicken, Zebrafish
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免疫原
Synthetic peptide:
CNVNSGDGIDYSQ
, corresponding to amino acids 188 - 199 of Human PACRG. -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.87% Sodium chloride -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
This is an affinity purified antibody produced by immunoaffinity chromatography using the immunizing peptide after immobilization to a solid phase. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/3000. Detects a band of approximately 40 kDa (predicted molecular weight: 33 kDa).
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| 说明 |
|---|
|
WB
1/500 - 1/3000. Detects a band of approximately 40 kDa (predicted molecular weight: 33 kDa). |
靶标
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功能
Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. -
组织特异性
Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients. - Information by UniProt
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数据库链接
- Entrez Gene: 69310 Mouse
- Entrez Gene: 499021 Rat
- SwissProt: Q9DAK2 Mouse
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别名
- FLJ32724 antibody
- GLUP antibody
- HAK005771 antibody
see all
图片
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Western blot - Anti-PACRG antibody (ab4090)All lanes : Anti-PACRG antibody (ab4090) at 1/1500 dilution
Lane 1 : Mouse embryonic fibroblast (MEF) whole cell lysate
Lane 2 : Mouse embryonic fibroblast (MEF) whole cell lysate with immunising peptide
Lysates/proteins at 35 µg per lane.
Secondary
All lanes : IRDye 800 conjugated Goat anti-Rabbit IgG [H&L] at 1/10000 dilution
Predicted band size: 33 kDa
Observed band size: 40 kDa why is the actual band size different from the predicted?
数据表及文件
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Datasheet download
文献 (1)
ab4090 被引用在 1 文献中.
- Gavino C & Richard S Patched1 haploinsufficiency impairs ependymal cilia function of the quaking viable mice, leading to fatal hydrocephalus. Mol Cell Neurosci 47:100-7 (2011). PubMed: 21447392
