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Signal Transduction Protein Phosphorylation Ser / Thr Kinases MAPK Pathway

Anti-p38 (phospho T180 + Y182)抗体(ab4822)

  • Datasheet
  • SDS
Reviews (5)Q&A (3)References (144)

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Western blot - Anti-p38 (phospho T180 + Y182) antibody (ab4822)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p38 (phospho T180 + Y182) antibody (ab4822)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p38 (phospho T180 + Y182) antibody (ab4822)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p38 (phospho T180 + Y182) antibody (ab4822)
  • Immunocytochemistry/ Immunofluorescence - Anti-p38 (phospho T180 + Y182) antibody (ab4822)
  • Western blot - Anti-p38 (phospho T180 + Y182) antibody (ab4822)

Key features and details

  • Rabbit polyclonal to p38 (phospho T180 + Y182)
  • Suitable for: IHC-P, ICC/IF, WB
  • Reacts with: Rat, Human
  • Isotype: IgG

选择批间可重复性更高的重组抗体

Product image
Anti-p38 (phospho T180 + Y182) antibody [EPR18120] (ab195049)
  • 研究可靠 —— 各批次间结果一致且可重复
  • 长期批量供应 —— 采用重组技术,可实现快速生产
  • 首次实验即可成功 —— 经过大量验证确认了特异性
  • 符合伦理标准 —— 产品不含动物成分

概述

  • 产品名称

    Anti-p38 (phospho T180 + Y182)抗体
    参阅全部 p38 一抗
  • 描述

    兔多克隆抗体to p38 (phospho T180 + Y182)
  • 宿主

    Rabbit
  • 经测试应用

    适用于: IHC-P, ICC/IF, WBmore details
  • 种属反应性

    与反应: Rat, Human
    预测可用于: Mouse, Dog, Carp, Monkey
  • 免疫原

    Synthetic peptide corresponding to Human p38 (phospho T180 + Y182). p38 is dually phosphorylated and therefore fully activated by MEK3 and MEK6 on threonine 180 and tyrosine 182 within the activation loop.
    Database link: Q16539
    (Peptide available as ab5253)

  • 阳性对照

    • WB: HeLa, A431, COLO 205, A549 and A549 cell lysate; HEK-293 (human epithelial cell line from embryonic kidney) cells. IHC-P: Human brain tissue, human heart tissue, rat heart tissue. ICC: SH-SY5Y (human neuroblastoma cell line from bone marrow) cells.
  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

  • 形式

    Liquid
  • 存放说明

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
  • 存储溶液

    pH: 7.30
    Preservative: 0.05% Sodium azide
    Constituents: PBS, 50% Glycerol, 0.1% BSA

    BSA is IgG and protease free. PBS without Mg2+ and Ca2+.
  • Concentration information loading...
  • 纯度

    Protein A purified
  • 纯化说明

    Purified from rabbit serum by sequential epitope-specific chromatography. The antibody has been negatively preadsorbed using i) non-phosphopeptide corresponding to the site of phosphorylation to remove antibody that is reactive with non-phosphorylated p38, and ii) a JNK-derived peptide that is phosphorylated at threonine 183 and tyrosine 185. The final product is generated by affinity chromatography using a p38-derived peptide that is phosphorylated at threonine 180 and tyrosine 182.
  • 克隆

    多克隆
  • 同种型

    IgG
  • 研究领域

    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • MAPK Pathway
    • Immunology
    • Innate Immunity
    • TLR Signaling
    • Neuroscience
    • Development
    • Neuroscience
    • Processes

相关产品

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human p38 alpha/MAPK14 protein (ab82188)
  • Related Products

    • Human p38 (phospho T180 + Y182) peptide (ab58397)

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab4822于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
IHC-P
1/10 - 1/100.
ICC/IF
1/250.
WB (3)
1/1000. Predicted molecular weight: 38 kDa.
说明
IHC-P
1/10 - 1/100.
ICC/IF
1/250.
WB
1/1000. Predicted molecular weight: 38 kDa.

靶标

  • 功能

    Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.
  • 组织特异性

    Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
  • 序列相似性

    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • 结构域

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • 翻译后修饰

    Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位

    Cytoplasm. Nucleus.
  • Target information above from: UniProt accession Q16539 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 数据库链接

    • Entrez Gene: 403856 Dog
    • Entrez Gene: 1432 Human
    • Entrez Gene: 26416 Mouse
    • Entrez Gene: 81649 Rat
    • Omim: 600289 Human
    • SwissProt: O02812 Dog
    • SwissProt: Q16539 Human
    • SwissProt: P47811 Mouse
    • SwissProt: P70618 Rat
    • Unigene: 485233 Human
    • Unigene: 311337 Mouse
    • Unigene: 88085 Rat
    see all
  • 别名

    • CSAID Binding Protein 1 antibody
    • CSAID binding protein antibody
    • CSAID-binding protein antibody
    • Csaids binding protein antibody
    • CSBP 1 antibody
    • CSBP 2 antibody
    • CSBP antibody
    • CSBP1 antibody
    • CSBP2 antibody
    • CSPB1 antibody
    • Cytokine suppressive anti-inflammatory drug-binding protein antibody
    • EXIP antibody
    • MAP kinase 14 antibody
    • MAP kinase MXI2 antibody
    • MAP kinase p38 alpha antibody
    • MAPK 14 antibody
    • MAPK14 antibody
    • MAX interacting protein 2 antibody
    • MAX-interacting protein 2 antibody
    • Mitogen Activated Protein Kinase 14 antibody
    • Mitogen activated protein kinase p38 alpha antibody
    • Mitogen-activated protein kinase 14 antibody
    • Mitogen-activated protein kinase p38 alpha antibody
    • MK14_HUMAN antibody
    • Mxi 2 antibody
    • MXI2 antibody
    • p38 ALPHA antibody
    • p38 antibody
    • p38 MAP kinase antibody
    • p38 MAPK antibody
    • p38 mitogen activated protein kinase antibody
    • p38ALPHA antibody
    • p38alpha Exip antibody
    • PRKM14 antibody
    • PRKM15 antibody
    • RK antibody
    • SAPK2A antibody
    • Stress-activated protein kinase 2a antibody
    see all

图片

  • Western blot - Anti-p38 (phospho T180 + Y182) antibody (ab4822)
    Western blot - Anti-p38 (phospho T180 + Y182) antibody (ab4822)
    All lanes : Anti-p38 (phospho T180 + Y182) antibody (ab4822) at 1/1000 dilution

    Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate
    Lane 2 : HeLa (human epithelial cell line from cervix adenocarcinoma) exposed for 40 min with UV, cell lysate
    Lane 3 : A431 (human epidermoid carcinoma cell line) cell lysate
    Lane 4 : A431 (human epidermoid carcinoma cell line) exposed for 40 min with UV, cell lysate
    Lane 5 : COLO 205 (human colon adenocarcinoma cell line) cell lysate
    Lane 6 : COLO 205 (human colon adenocarcinoma cell line) exposed for 40 min with UV, cell lysate
    Lane 7 : A549 (human lung carcinoma cell line) cell lysate
    Lane 8 : A549 (human lung carcinoma cell line) exposed for 40 min with UV, cell lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    All lanes : Goat anti-Rabbit IgG HRP at 1/5000 dilution

    Developed using the ECL technique.

    Predicted band size: 38 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p38 (phospho T180 + Y182) antibody (ab4822)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p38 (phospho T180 + Y182) antibody (ab4822)

    Paraffin-embedded human brain tissue stained for p38 (phospho T180 + Y182) using ab4822 (right panel) at 1/100 dilution in immunohistochemical analysis followed by HRP-conjugated secondary antibody and DAB staining. Negative control (left panel) staining without primary antibody. 

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p38 (phospho T180 + Y182) antibody (ab4822)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p38 (phospho T180 + Y182) antibody (ab4822)

    Paraffin-embedded human heart tissue stained for p38 (phospho T180 + Y182) using ab4822 (right panel) at 1/20 dilution in immunohistochemical analysis followed by HRP-conjugated secondary antibody and DAB staining. Negative control (left panel) staining without primary antibody.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p38 (phospho T180 + Y182) antibody (ab4822)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p38 (phospho T180 + Y182) antibody (ab4822)

    Paraffin-embedded rat heart tissue stained for p38 (phospho T180 + Y182) using ab4822 (right panel) at 1/20 dilution in immunohistochemical analysis followed by HRP-conjugated secondary antibody and DAB staining. Negative control (left panel) staining without primary antibody.

  • Immunocytochemistry/ Immunofluorescence - Anti-p38 (phospho T180 + Y182) antibody (ab4822)
    Immunocytochemistry/ Immunofluorescence - Anti-p38 (phospho T180 + Y182) antibody (ab4822)

    4% PFA-fixed, Triton X-100 permeabilized SH-SY5Y (human neuroblastoma cell line from bone marrow) cells labeling p38 (phospho T180 + Y182) (Panel A: green) using ab4822 at 1 µg/mL in ICC/IF. Secondary antibody: Alexa Flour® 488 Goat Anti-Rabbit IgG at 1/400 dilution. Nuclei (Panel b: blue) were stained with SlowFade® Gold Antifade Mountant with DAPI. F-actin (Panel c: red) was stained with Alexa Fluor® 594 Phalloidin. Panel d is a merged image showing nuclear localization. Panel e is a no primary antibody control. 

     
  • Western blot - Anti-p38 (phospho T180 + Y182) antibody (ab4822)
    Western blot - Anti-p38 (phospho T180 + Y182) antibody (ab4822)

    Peptide Competition: Extracts prepared from HEK-293 (human epithelial cell line from embryonic kidney) cells treated with UV irradiation were resolved on a 10% Tris-glycine gel and transferred to nitrocellulose. Membranes were blocked with a 5% BSA-TBST buffer overnight at 4oC, then were incubated with 0.50 µg/mL ab4822 for two hours at room temperature in a 3% BSA-TBST buffer, following its prior incubation with: the peptide immunogen (1), a generic phosphothreonine containing peptide (2), a generic phosphotyrosine-containing peptide (3), the non-phosphorylated peptide corresponding to the phosphopeptide (4), no peptide (5), the phosphorylated peptide derived from the corresponding region of JNK 1 & 2 (6), and, the phosphorylated peptide derived from the corresponding region of ERK 1 & 2 (7). After washing, membranes were incubated with goat F(ab')2 antirabbit IgG alkaline phosphatase and the signal was detected using the Tropix WesternStar method. The data show that only the phosphopeptide

实验方案

  • Peptide Competition Experiment
  • Western blotting protocol

Click here to view the general protocols

数据表及文件

  • SDS download

  • Datasheet download

    Download

文献 (144)

发表研究结果有使用 ab4822?请让我们知道,以便我们可以引用本数据表中的参考文章。

ab4822 被引用在 144 文献中.

  • Sun P  et al. Hsp90 modulates human sperm capacitation via the Erk1/2 and p38 MAPK signaling pathways. Reprod Biol Endocrinol 19:39 (2021). PubMed: 33663544
  • Xiong L  et al. Tectoridin inhibits the progression of colon cancer through downregulating PKC/p38 MAPK pathway. Mol Cell Biochem 476:2729-2738 (2021). PubMed: 33683556
  • Wang K  et al. Vertebral-specific activation of the CX3CL1/ICAM-1 signaling network mediates non-small-cell lung cancer spinal metastasis by engaging tumor cell-vertebral bone marrow endothelial cell interactions. Theranostics 11:4770-4789 (2021). PubMed: 33754027
  • Hu HJ  et al. Hydrogen sulfide improves ox-LDL-induced expression levels of Lp-PLA2 in THP-1 monocytes via the p38MAPK pathway. Mol Med Rep 23:N/A (2021). PubMed: 33760156
  • Wang C  et al. Proof-of-concept study investigating the role of S100P-RAGE in nasopharyngeal carcinoma. Exp Ther Med 21:470 (2021). PubMed: 33767765
View all Publications for this product

客户评价及客户问答

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1-8 of 8 Abreviews or Q&A

Western blot abreview for Anti-p38 (phospho T180 + Y182) antibody

Poor
Abreviews
Abreviews
abreview image
Application
Western blot
Sample
Dog Cell lysate - whole cell (MDCK)
Gel Running Conditions
Reduced Denaturing (12%)
Loading amount
10 µg
Treatment
100 pM IL-1β
Specification
MDCK
Blocking step
BlockAce as blocking agent for 50 minute(s) · Concentration: 100% · Temperature: 25°C
Read More

DR. 令 中野

Verified customer

提交于 Jul 14 2017

Immunohistochemistry (Frozen sections) abreview for Anti-p38 (phospho T180 + Y182) antibody

Excellent
Abreviews
Abreviews
Application
Immunohistochemistry (Frozen sections)
Sample
Mouse Tissue sections (Neonatal Cochlear Hair Cells)
Permeabilization
Yes - triton X
Specification
Neonatal Cochlear Hair Cells
Blocking step
Serum as blocking agent for 30 minute(s) · Concentration: 2% · Temperature: 22°C
Fixative
Paraformaldehyde
Read More

Abcam user community

Verified customer

提交于 Feb 11 2021

Immunohistochemistry (Frozen sections) abreview for Anti-p38 (phospho T180 + Y182) antibody

Excellent
Abreviews
Abreviews
abreview image
Application
Immunohistochemistry (Frozen sections)
Blocking step
BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1% · Temperature: 21°C
Sample
Mouse Tissue sections (retina)
Specification
retina
Permeabilization
Yes - triton x100
Fixative
Paraformaldehyde
Read More

PROF. Minzhong Yu

Verified customer

提交于 Feb 27 2015

Western blot abreview for Anti-p38 (phospho Y182 + T180) antibody

Good
Abreviews
Abreviews
abreview image
Application
Western blot
Sample
Mouse Tissue lysate - whole (skeletal muscle)
Loading amount
20 µg
Specification
skeletal muscle
Gel Running Conditions
Reduced Denaturing (Bis-Tris 4-12% MOPS running buffer)
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 20°C
Read More

Abcam user community

Verified customer

提交于 Feb 25 2008

Western blot abreview for Anti-p38 (phospho Y182 + T180) antibody

Good
Abreviews
Abreviews
abreview image
Application
Western blot
Sample
Human Cell lysate - whole cell (Human Caco-2 epithelial colorectal adenocarcinoma)
Loading amount
10 µg
Specification
Human Caco-2 epithelial colorectal adenocarcinoma
Gel Running Conditions
Reduced Denaturing
Blocking step
BSA as blocking agent for 16 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 4°C
Read More

Abcam user community

Verified customer

提交于 Jan 06 2011

Question

I ordered one antibody which is Phopho-P38 (AB4822) from you, order number: Neuro_58510.
but this antibody is not working well in mouse brain samples, please check in attached PPT
file. This blot was developed first with Histone H3, which gave very good signal, but with the
Phopho-P38 antibody, it didn't show any signal in the right molecular weight.

I am wondering what options do I have, such as refund or select another antibody as an alternative.
Thank you.

Best regards,

Read More

Abcam community

Verified customer

Asked on Feb 01 2013

Answer

Thank you for your email. I am sorry to hear that you have been experiencing problems with this antibody.

I have read the details you have kindly provided and have following further questions for better understanding of the problem;

Sample preparation (cell type, species, lysis buffer, protease inhibitors, phosphatase inhibitors)
Amount of protein loaded
Electrophoresis and transfer conditions
Blocking conditions
Primary antibody conditions (diluent/dilution, incubation time/temperature)
Secondary antibody conditions (diluent/dilution, incubation time/temperature)
Wash steps and buffer
Detection method
Controls used (sample, alternative primary ab, no primary)
Lot number/order number/date of purchase



Thank you very much for your cooperation. I will look forward to hearing from you soon.

Read More

Abcam Scientific Support

回复于 Feb 01 2013

Question

Dear technical support: This customer raised an inquiry about ab4822 (Anti-p38 (phospho Y182 + T180) antibody), and this customer used this antibody conduct the western blot assay with human sample, and the data shows the multiple bean and no specific bean, because this antibody is already out of our warranty period, therefore she only wants to know which bean is the correct size of p-P38 in her western blot image. I attach the western blot data and the WB questionnaire in this letter, could you please help this customer to solve this problem. Thanks for your kindly assistance.

Read More

Abcam community

Verified customer

Asked on Sep 15 2011

Answer

Thank you for contacting us. I am sorry to hear the customer has been having problems with this antibody. I think the right band is being detected at ~55 kDa. I would like to suggest some tips that might help improve the results: - Decrease the amount of antibody to 1:6000 - Load ~10ug of sample. - Use 5% BSA for blocking and antibody incubations, do not use milk as it contains casein which is a phosphoprotein. This can cause high background because the phospho-specific antibody detects the casein present in the milk. I hope this advice helps improve the results. Please do not hesitate to contact me should you have further questions.

Read More

Abcam Scientific Support

回复于 Sep 15 2011

Question

What is the concentration? Abcam lot 122007.

Read More

Abcam community

Verified customer

Asked on Aug 11 2005

Answer

Thank you for your enquiry and patience. The concentration for this batch is 0.125 mg/ml. If you have any additional questions, please contact us again.

Read More

Abcam Scientific Support

回复于 Aug 16 2005

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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