Anti-Oxytocin-neurophysin 1抗体(ab2078)

Reviews (2)Q&A (3)References (14)

Key features and details

  • Rabbit polyclonal to Oxytocin-neurophysin 1
  • Reacts with: Mouse, Rat, Sheep, Rabbit, Human, Pig
  • Isotype: IgG

概述

  • 产品名称

    Anti-Oxytocin-neurophysin 1抗体
    参阅全部 Oxytocin-neurophysin 1 一抗

  • 描述

    兔多克隆抗体to Oxytocin-neurophysin 1

  • 宿主

    Rabbit

  • 特异性

    Less than 1% reactivity to vasopressin.

  • 种属反应性

    与反应: Mouse, Rat, Sheep, Rabbit, Human, Pig

  • 免疫原

    Other Immunogen Type corresponding to Oxytocin-neurophysin 1. Immunogen: oxytocin-thyroglobulin

  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

性能

靶标

  • 相关性

    Neurophysin 1 specifically binds oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. Oxytocin contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.

  • 细胞定位

    Secreted

  • 数据库链接

    see all

  • 别名

    • MGC126890 antibody
    • MGC126892 antibody
    • Neurophysin 1 antibody
    • Neurophysin I antibody
    • Ocytocin antibody
    • OT antibody
    • OT NPI antibody
    • OXT antibody
    • Oxytocin Neurophysin preproprotein antibody
    • Oxytocin prepro (neurophysin I) antibody
    • Oxytocin prepropeptide antibody
    • Oxytocin-neurophysin 1 antibody
    see all

文献 (14)

发表研究结果有使用 ab2078？请让我们知道，以便我们可以引用本数据表中的参考文章。

ab2078 被引用在 14 文献中.

  • Ogata K  et al. Lavender Oil Reduces Depressive Mood in Healthy Individuals and Enhances the Activity of Single Oxytocin Neurons of the Hypothalamus Isolated from Mice: A Preliminary Study. Evid Based Complement Alternat Med 2020:5418586 (2020). PubMed: 32733584
  • Song TJ  et al. Altered Behaviors and Impaired Synaptic Function in a Novel Rat Model With a Complete Shank3 Deletion. Front Cell Neurosci 13:111 (2019). PubMed: 30971895
  • Mohan S  et al. Oxytocin is present in islets and plays a role in beta-cell function and survival. Peptides 100:260-268 (2018). IF . PubMed: 29274352
  • Zhang B  et al. Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation. Sci Rep 8:10415 (2018). PubMed: 29991705
  • Dai D  et al. Direct Involvement of Androgen Receptor in Oxytocin Gene Expression: Possible Relevance for Mood Disorders. Neuropsychopharmacology 42:2064-2071 (2017). PubMed: 28447621
View all Publications for this product

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Immunohistochemistry (Frozen sections) abreview for Anti-Oxytocin-neurophysin 1 antibody

 Good
Abreviews
abreview image
Application
Immunohistochemistry (Frozen sections)
Sample
Mouse Tissue sections (Brain)
Permeabilization
Yes - 0.1% Triton X-100
Specification
Brain
Blocking step
Serum as blocking agent for 24 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 4°C
Fixative
Paraformaldehyde
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Kevin Zhang

Verified customer

提交于 Jan 31 2018

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-Oxytocin antibody

 Good
Abreviews
abreview image
Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step
hydrogen peroxide as blocking agent for 10 minute(s) · Concentration: 3% · Temperature: 25°C
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: citrate, pH6.0, 100C 20 min
Sample
Human Tissue sections (placenta)
Specification
placenta
Permeabilization
No
Fixative
Formaldehyde
Read More

Abcam user community

Verified customer

提交于 Jul 01 2014

Question

Dear ladies and gentleman, I am interestet in the anti-OT and anti-AVP antibodies from this paper: PLoS One. 2011;6(8):e23362. Epub 2011 Aug 17. Oxytocin and vasopressin involved in restraint water-immersion stress mediated by oxytocin receptor and vasopressin 1b receptor in rat brain. Zhao DQ, Ai HB. unfortunately in the refference list of all of your antibodies i couldn´t find this paper, although they had their antibodies from your company. can you please help me?

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Answer

Thank you for your inquiry. Unfortunately, we are unable to track down the particular antibodies the authors used when it is not specifically mentioned in the paper. However, the following antibodies might have been used: ab39363: anti-Vasopressin (AVP), guaranteed to work in immunohistochemistry (PFA perfusion fixed frozen sections and frozen sections, IHC-FoFr, IHC-Fr) on rat. Click here (or use the following: https://www.abcam.com/Vasopressin-antibody-ab39363.html). ab2078: anti-Oxytocin, guaranteed to work in RIA and immunohistochemistry (PFA perfusion fixed frozen sections and paraffin-embedded sections, IHC-FoFr, IHC-P) on rat. Click here (or use the following: https://www.abcam.com/Oxytocin-neurophysin-1-antibody-ab2078.html). ab11143: anti-Oxytocin, guaranteed to work in immunohistochemistry (frozen sections, IHC-Fr) on rat. Click here (or use the following: https://www.abcam.com/Oxytocin-neurophysin-1-antibody-ab11143.html). ab78364: anti-Oxytocin, guaranteed to work in ELISA and immunohistochemistry (PFA perfusion fixed frozen sections and paraffin-embedded sections, IHC-FoFr, IHC-P) on rat. Click here (or use the following: https://www.abcam.com/Oxytocin-neurophysin-1-antibody-4G11-ab78364.html). We are happy to reassure you that all of our products are covered by our Abpromise, which guarantees that the product will work in the applications and species specified on the datasheet, or we will offer a replacement, credit, or refund within 6 months of purchase. If the product is to be used in an untested species or application, you may be eligible for our testing discount program if the antibody has not yet been purchased. Please contact our Scientific Support team by replying to this email prior to purchase for more information. I hope this information is helpful. Please do not hesitate to contact us again with any other questions.

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Question

I am setting up an RIA to measure oxytocin in rabbit serum and thought your ab 2078 would work. On your website it is listed as having been tested for RIA, do you have a protocol available? Any information regarding this application of ab2078 would be appreciated.

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Answer

Thank you for your enquiry. I am sorry but we do not have an online RIA protocol. However, I would like to recommmend the following resources: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=716433&dopt=Abstract http://www.phoenixpeptide.com/qcdata/RIK/protocol10-1280_p.pdf http://faculty.washington.edu/jwingfie/protocols.html I hope this information helps, please do not hesitate to contact us if you need any more advice or information.

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Question

Thank you for your quick answer. I know that sometimes antibodies against vasopressin and oxytocin are using for immunostaining of vasotocin and isotocin. I would like to ask you if it's possible to use your antibodies ab8745 (anti-vasopressin) or ab2078 (anti- oxytocin) for vasotocin or isotocin staining? Could you inform me about cross-reaction of ab8745 and ab2078 with vasotocin or isotocin, please.I will be very grateful for your help.

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Answer

Thank you for your enquiry regarding our antibodies ab2078 and ab8745. Unfortunately we do not have any further information regarding their cross reactivity with vasotocin or isotocin, this has not been tested in our laboratories. I'm very sorry I couldn't help you more on this occasion,

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