Anti-ORC1抗体[7F6/1] - ChIP Grade (ab60)
Key features and details
- Mouse monoclonal [7F6/1] to ORC1 - ChIP Grade
- Suitable for: WB, ChIP
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-ORC1抗体[7F6/1] - ChIP Grade
参阅全部 ORC1 一抗 -
描述
小鼠单克隆抗体[7F6/1] to ORC1 - ChIP Grade -
宿主
Mouse -
经测试应用
适用于: WB, ChIPmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein (Human)
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阳性对照
- HeLa cells.
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
7F6/1 -
骨髓瘤
Sp2/0-Ag14 -
同种型
IgG1 -
轻链类型
unknown -
研究领域
相关产品
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ChIP Related Products
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Compatible Secondaries
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Isotype control
应用
Our Abpromise guarantee covers the use of ab60 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/1250 - 1/2500. Detects a band of approximately 120 kDa (predicted molecular weight: 97 kDa). | |
| ChIP | Use at an assay dependent dilution. |
靶标
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功能
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. -
序列相似性
Belongs to the ORC1 family.
Contains 1 BAH domain. -
发展阶段
Expression is cell-cycle regulated, it starts to accumulate in mid-G1 phase, reaches a peak at the G1/S boundary, and decreases to a basal level in S phase (at protein level). -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 4998 Human
- Omim: 601902 Human
- SwissProt: Q13415 Human
- Unigene: 17908 Human
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别名
- HSORC1 antibody
- MmORC1 antibody
- orc1 antibody
see all
数据表及文件
文献 (3)
ab60 被引用在 3 文献中.
- Lu F et al. Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases. Biol Open 5:1449-1460 (2016). PubMed: 27744293
- Beck DB et al. The role of PR-Set7 in replication licensing depends on Suv4-20h. Genes Dev 26:2580-9 (2012). WB, ChIP ; Human . PubMed: 23152447
- Salsi V et al. HOXD13 binds DNA replication origins to promote origin licensing and is inhibited by geminin. Mol Cell Biol 29:5775-88 (2009). ChIP ; Human, Mouse . PubMed: 19703996
