Key features and details
- Mouse monoclonal [7F6/1] to ORC1 - ChIP Grade
- Suitable for: WB, ChIP
- Reacts with: Human
- Isotype: IgG1
存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Concentration information loading...
纯度Protein A purified
ChIP Related Products
Our Abpromise guarantee covers the use of ab60 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1250 - 1/2500. Detects a band of approximately 120 kDa (predicted molecular weight: 97 kDa).|
|ChIP||Use at an assay dependent dilution.|
功能Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
序列相似性Belongs to the ORC1 family.
Contains 1 BAH domain.
发展阶段Expression is cell-cycle regulated, it starts to accumulate in mid-G1 phase, reaches a peak at the G1/S boundary, and decreases to a basal level in S phase (at protein level).
- Information by UniProt
- HSORC1 antibody
- MmORC1 antibody
- orc1 antibody
ab60 被引用在 3 文献中.
- Lu F et al. Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases. Biol Open 5:1449-1460 (2016). PubMed: 27744293
- Beck DB et al. The role of PR-Set7 in replication licensing depends on Suv4-20h. Genes Dev 26:2580-9 (2012). WB, ChIP ; Human . PubMed: 23152447
- Salsi V et al. HOXD13 binds DNA replication origins to promote origin licensing and is inhibited by geminin. Mol Cell Biol 29:5775-88 (2009). ChIP ; Human, Mouse . PubMed: 19703996