Anti-ORC1抗体[7F6/1] - ChIP Grade (ab60)
概述
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产品名称Anti-ORC1抗体[7F6/1] - ChIP Grade
参阅全部 ORC1 一抗 -
描述小鼠单克隆抗体[7F6/1] to ORC1 - ChIP Grade
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宿主Mouse
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经测试应用适用于: WB, ChIPmore details
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种属反应性与反应: Human
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免疫原
Recombinant full length protein (Human)
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阳性对照
- HeLa cells.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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Concentration information loading...
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纯度Protein A purified
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克隆单克隆
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克隆编号7F6/1
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骨髓瘤Sp2/0-Ag14
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同种型IgG1
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轻链类型unknown
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研究领域
相关产品
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Alternative Versions
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ChIP Related Products
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Compatible Secondaries
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Isotype control
应用
Our Abpromise guarantee covers the use of ab60 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用 | Ab评论 | 说明 |
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WB | 1/1250 - 1/2500. Detects a band of approximately 120 kDa (predicted molecular weight: 97 kDa). | |
ChIP | Use at an assay dependent dilution. |
靶标
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功能Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
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序列相似性Belongs to the ORC1 family.
Contains 1 BAH domain. -
发展阶段Expression is cell-cycle regulated, it starts to accumulate in mid-G1 phase, reaches a peak at the G1/S boundary, and decreases to a basal level in S phase (at protein level).
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细胞定位Nucleus.
- Information by UniProt
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数据库链接
- Entrez Gene: 4998 Human
- Omim: 601902 Human
- SwissProt: Q13415 Human
- Unigene: 17908 Human
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别名
- HSORC1 antibody
- MmORC1 antibody
- orc1 antibody
see all
数据表及文件
文献
This product has been referenced in:
- Lu F et al. Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases. Biol Open 5:1449-1460 (2016). Read more (PubMed: 27744293) »
- Beck DB et al. The role of PR-Set7 in replication licensing depends on Suv4-20h. Genes Dev 26:2580-9 (2012). WB, ChIP ; Human . Read more (PubMed: 23152447) »