Key features and details
- Rabbit polyclonal to NT-4
- Reacts with: Human
- Isotype: IgG
参阅全部 NT-4 一抗
特异性Less than 1% cross reactivity against NGF, BDNF and NT3 by dot blot. Cross reactivity: Known to react with human NT4. Not yet tested against other species.
Recombinant full length protein (Human).
The concentrations of NT4 are generally very low in most tissues. A good positive control is neonatal testes of rat (Zhang et al, 1999).
Previously labelled as Neurotrophin 4.
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Concentration information loading...
纯度Protein G purified
Western Blot: 1-2 ug/ml
Immunoblot: 1-2 ug/ml
1 site ELISA: 0.5 ug/ml
Biological Inhibition: 2-10 ug/ml (ED50)
功能Target-derived survival factor for peripheral sensory sympathetic neurons.
组织特异性Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
疾病相关Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:613100]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
序列相似性Belongs to the NGF-beta family.
- Information by UniProt
- GLC10 antibody
- GLC1O antibody
- Neurotrophic factor 4 antibody
ab6205 被引用在 1 文献中.
- Zhang Y et al. Transcriptome Landscape of Human Folliculogenesis Reveals Oocyte and Granulosa Cell Interactions. Mol Cell 72:1021-1034.e4 (2018). PubMed: 30472193