Anti-NT-4抗体(ab6205)
Key features and details
- Rabbit polyclonal to NT-4
- Suitable for: Dot blot, ELISA, IHC-Fr, Neutralising, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-NT-4抗体
参阅全部 NT-4 一抗 -
描述
兔多克隆抗体to NT-4 -
宿主
Rabbit -
特异性
Less than 1% cross reactivity against NGF, BDNF and NT3 by dot blot. Cross reactivity: Known to react with human NT4. Not yet tested against other species. -
经测试应用
适用于: Dot blot, ELISA, IHC-Fr, Neutralising, WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein (Human).
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常规说明
The concentrations of NT4 are generally very low in most tissues. A good positive control is neonatal testes of rat (Zhang et al, 1999). This antibody has been shown useful for quantitative ELISA, immunohistochemistry of lesioned brain as well as for western blot and inhibition of biological activityPreviously labelled as Neurotrophin 4.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Constituent: PBS -
Concentration information loading... -
纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
Our Abpromise guarantee covers the use of ab6205 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Dot blot | ||
| ELISA | ||
| IHC-Fr | ||
| Neutralising | ||
| WB |
应用说明
Immunohistochemistry: 1-2 ug/ml
Western Blot: 1-2 ug/ml
Immunoblot: 1-2 ug/ml
1 site ELISA: 0.5 ug/ml
Biological Inhibition: 2-10 ug/ml (ED50)
Western Blot: 1-2 ug/ml
Immunoblot: 1-2 ug/ml
1 site ELISA: 0.5 ug/ml
Biological Inhibition: 2-10 ug/ml (ED50)
靶标
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功能
Target-derived survival factor for peripheral sensory sympathetic neurons. -
组织特异性
Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues. -
疾病相关
Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:613100]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. -
序列相似性
Belongs to the NGF-beta family. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 4909 Human
- Omim: 162662 Human
- SwissProt: P34130 Human
- Unigene: 266902 Human
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别名
- GLC10 antibody
- GLC1O antibody
- Neurotrophic factor 4 antibody
see all
数据表及文件
文献 (1)
ab6205 被引用在 1 文献中.
- Zhang Y et al. Transcriptome Landscape of Human Folliculogenesis Reveals Oocyte and Granulosa Cell Interactions. Mol Cell 72:1021-1034.e4 (2018). PubMed: 30472193
