Anti-Noxa抗体[ABM46B8] (ab220177)
Key features and details
- Rat monoclonal [ABM46B8] to Noxa
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG2b
概述
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产品名称
Anti-Noxa抗体[ABM46B8]
参阅全部 Noxa 一抗 -
描述
大鼠单克隆抗体[ABM46B8] to Noxa -
宿主
Rat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Recombinant full length protein corresponding to Mouse Noxa aa 1 to the C-terminus.
Database link: Q9JM54 -
阳性对照
- T98G lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
ABM46B8 -
同种型
IgG2b -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab220177于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
Use a concentration of 2 - 4 µg/ml. Predicted molecular weight: 12 kDa.
Predicted Band: 6kDa (Human) |
说明 |
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WB
Use a concentration of 2 - 4 µg/ml. Predicted molecular weight: 12 kDa. Predicted Band: 6kDa (Human) |
靶标
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功能
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. -
组织特异性
Highly expressed in adult T-cell leukemia cell line. -
序列相似性
Belongs to the PMAIP1 family. -
结构域
The BH3 motif is essential for pro-apoptotic activity. -
细胞定位
Mitochondrion. - Information by UniProt
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数据库链接
- Entrez Gene: 5366 Human
- Entrez Gene: 58801 Mouse
- Omim: 604959 Human
- SwissProt: Q13794 Human
- SwissProt: Q9JM54 Mouse
- Unigene: 96 Human
- Unigene: 271878 Mouse
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别名
- Adult T cell leukemia derived PMA responsive antibody
- APR antibody
- APR_HUMAN antibody
see all
数据表及文件
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Datasheet download
文献 (0)
ab220177 尚未被引用在任何文献中。