Neuroepithelial cell markers
A guide to choosing markers to label neuroepithelial cells
Neuroepithelial (NE) cells are symmetrically dividing cells that form the neural plate and neural tube during embryonic development. They exhibit typical epithelial features such as tight junctions and are highly polarized along their apical-basal axis.
Nestin An intermediate filament protein expressed in NE cells. Its expression persists in radial glia until astrocyte development. iPSCs stained with anti-nestin (red)( ab105389).
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SOX2 A transcription factor and the earliest marker of the neural plate. It is expressed in proliferating cells and those that acquire glial fates, but downregulated in post-mitotic neurons. E13 mouse spinal cord sections stained with anti-SOX2 ( ab97959).
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Occludin A tight junction protein lost after neural tube closure prior to neurogenesis. Human breast cancer cells stained with anti-occludin (red) ( ab31721).
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E-cadherin Cell adhesion molecule downregulated after neural tube closure prior to neurogenesis. Human pluripotent stem cells stained with anti-E-cadherin ( ab40772).
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