Glutamatergic neuron markers

At-a-glance- guide to glutamatergic neuron markers

Glutamatergic neurons produce glutamate, which is one of the most common excitatory neurotransmitters in the central nervous system (CNS).

A glutamate transporter that transports cytoplasmic glutamate into vesicles.

Zebrafish retina sections stained with anti-vGluT1 (green) (ab77822).

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A glutamate transporter that transports cytoplasmic glutamate into vesicles.

Mouse brain tissue sections stained with anti-vGluT2 (ab79157).

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An essential subunit of all NMDA receptors. 

Rat cortex stained with anti-NMDAR1 (ab17345).

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NMDAR1 modulators

(+)-MK 801 maleate (Dizocilpine) (ab120027)

Non-competitive NMDAR1 antagonist.  ion channel.

Memantine hydrochloride (ab120249)

NMDAR1 antagonist.

Eliprodil (ab145971)

Non-competitive specific inhibitor of NMDAR1 and/or NMDAR2B subunits.

Another NMDA receptor subunit. This subunit forms the glutamate binding site on the NMDA receptors.

Mouse cerebral cortex sections stained with anti-NMDAR2B (ab65783).

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NMDAR2B modulators

NGHVYEKLSSIE (Interfering peptide) (ab120380)

Peptide (agonist) that competes with clathrin adaptor protein (AP-2) binding to NR2B.

Eliprodil (ab145971)

Non-competitive specific inhibitor of NMDAR1 and/or NMDAR2B subunits.

Gentiopicrin (ab143623)

Downregulates GluN2B-containing NMDA receptors in the NAc.

Ro 25-6981 maleate salt (ab120290)

Potent, highly selective, activity-dependent inhibitor of NMDA receptors that contain the NR2B subunit.

Ifenprodil hemitartrate (ab120111)​

Non-competitive NMDAR2B antagonist acting at the polyamine site.


An enzyme catalyzing the deamination of glutamine into glutamate.

Human cerebral cortex tissue labeled with anti-glutaminase (ab156876).

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Glutamine synthetase

An enzyme catalyzing the ATP-dependent amidation of glutamate to form glutamine. It is primarily expressed in astrocytes but expression levels rise in neurons in neurodenegerative diseases. When staining for glutamine synthetase, we recommend parallel use of NeuN.

Zebrafish retina sections stained with anti-glutamine synthetase (purple) (ab93439).

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