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Neuroscience Neurotransmitter Neuropeptides Hormones

Anti-Neuropeptide Y抗体(ab6173)

  • Datasheet
  • SDS
Reviews (1)Q&A (3)References (13)

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Key features and details

  • Sheep polyclonal to Neuropeptide Y
  • Reacts with: Rabbit, Guinea pig, Human
  • Isotype: IgG

重组抗体的批间可重复性更强

Product image
Anti-Neuropeptide Y antibody [EPR21877] (ab221145)
  • 研究可靠 —— 各批次间结果一致且可重复
  • 长期批量供应 —— 采用重组技术,可实现快速生产
  • 首次实验即可成功 —— 经过大量验证确认了特异性
  • 符合伦理标准 —— 产品不含动物成分

概述

  • 产品名称

    Anti-Neuropeptide Y抗体
    参阅全部 Neuropeptide Y 一抗
  • 描述

    羊多克隆抗体to Neuropeptide Y
  • 宿主

    Sheep
  • 特异性

    The specificity of the NPY antiserum was determined by radioimmunoassay. Synthetic peptides, somatostatin-14, leu-enkephalin, met-enkephalin, oxytocin, Arg8-vasopressin, vasoactive intestinal peptide, angiotensin II demonstrated less than 0.005% cross- reactivity and substance P less than 0.02%. Peptide YY and bovine pancreatic polypeptide demonstrated approx. 36% and 0.05% cross- reactivity respectively. Human peptide YY share 65% homology amino acid sequence for human NPY. Synthetic NPY completely abolished radio labelled NPY binding to NPY antibody in RIA and antibody binding to tissue antigen.
  • 种属反应性

    与反应: Rabbit, Guinea pig, Human
  • 免疫原

    Synthetic peptide:

    TPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY

    , corresponding to amino acids 30-64 of Human Neuropeptide Y. The peptide was coupled to Bovine Thyroglobulin.
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

  • 形式

    Liquid
  • 存放说明

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Concentration information loading...
  • 纯度

    Whole antiserum
  • 克隆

    多克隆
  • 同种型

    IgG
  • 研究领域

    • Neuroscience
    • Neurotransmitter
    • Neuropeptides
    • Hormones
    • Neuroscience
    • Neurotransmitter
    • Neuropeptides
    • More Neuropeptides
    • Cardiovascular
    • Angiogenesis
    • Angiogenic Factors
    • Neuroscience
    • Neurology process
    • Metabolism
    • Cardiovascular
    • Heart
    • Hypertrophy
    • Other
    • Cardiovascular
    • Heart
    • Contractility
    • Inotropics
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    • Vasculature
    • Vasoconstriction
    • Other
    • Metabolism
    • Types of disease
    • Cancer

相关产品

  • Isotype control

    • Sheep IgG - Isotype Control (ab37385)
  • Recombinant Protein

    • Recombinant Human Neuropeptide Y protein (ab112330)

靶标

  • 功能

    NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
  • 组织特异性

    One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
  • 序列相似性

    Belongs to the NPY family.
  • 细胞定位

    Secreted.
  • Target information above from: UniProt accession P01303 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 数据库链接

    • Entrez Gene: 100724008 Guinea pig
    • Entrez Gene: 4852 Human
    • Omim: 162640 Human
    • SwissProt: P01303 Human
    • SwissProt: P68006 Rabbit
    • Unigene: 1832 Human
    • 别名

      • C-flanking peptide of NPY antibody
      • CPON antibody
      • Neuropeptide tyrosine antibody
      • Neuropeptide Y precursor antibody
      • NPY antibody
      • NPY_HUMAN antibody
      • Pro neuropeptide Y antibody
      • PYY 4 antibody
      • PYY4 antibody
      • Y Neuropeptide antibody
      see all

    实验方案

    • Immunohistochemistry protocols

    Click here to view the general protocols

    数据表及文件

    • SDS download

    • Datasheet download

      Download

    文献 (13)

    发表研究结果有使用 ab6173?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab6173 被引用在 13 文献中.

    • Shu Q  et al. Acupuncture Targeting SIRT1 in the Hypothalamic Arcuate Nucleus Can Improve Obesity in High-Fat-Diet-Induced Rats with Insulin Resistance via an Anorectic Effect. Obes Facts 13:40-57 (2020). PubMed: 31935731
    • Damasceno S  et al. Top Common Differentially Expressed Genes in the Epileptogenic Nucleus of Two Strains of Rodents Susceptible to Audiogenic Seizures: WAR and GASH/Sal. Front Neurol 11:33 (2020). PubMed: 32117006
    • Robinson SL  et al. Medial prefrontal cortex neuropeptide Y modulates binge-like ethanol consumption in C57BL/6J mice. Neuropsychopharmacology 44:1132-1140 (2019). PubMed: 30647448
    • Huang X  et al. Effects of electroacupuncture on luteal regression and steroidogenesis in ovarian hyperstimulation syndrome model rat. Life Sci 197:1-9 (2018). WB . PubMed: 29482802
    • Wang R  et al. Neuropeptide Y-Positive Neurons in the Dorsomedial Hypothalamus Are Involved in the Anorexic Effect of Angptl8. Front Mol Neurosci 11:451 (2018). PubMed: 30618603
    View all Publications for this product

    客户评价及客户问答

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    1-4 of 4 Abreviews or Q&A

    Immunohistochemistry (Frozen sections) abreview for Anti-Neuropeptide Y antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Frozen sections)
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: r.t°C
    Sample
    Rat Tissue sections (Brain)
    Specification
    Brain
    Permeabilization
    Yes - 0.2% Triton X-100
    Fixative
    Paraformaldehyde
    Read More

    Dr. Fabio Canneva

    Verified customer

    提交于 Jul 10 2014

    Question

    can I use the antibody on formaline fixed paraffine embbeded tissues?

    Read More

    Abcam community

    Verified customer

    Asked on Jul 13 2001

    Answer

    We cannot guarantee this antibody works on paraffin embedded tissues. It has not been tested for this.

    Read More

    Neil Hayward

    Abcam Scientific Support

    回复于 Aug 17 2001

    Question

    Dear Abcam: This antibody said to provide good staining in rabbit and guinea pig. Is it also good for staining of rat brain? Are there any other references to rat brain? Thank you

    Read More

    Abcam community

    Verified customer

    Asked on Jun 04 2001

    Answer

    This antibody has not been tested for staining rat brain, so its reactivity with rat NPY is unknown, although certainly possible. You may be able to estimate the likelihood of cross-reactivity with this species by comparing the sequence of the synthetic peptide immunogen with the sequences of rat, rabbit and guinea pig NPY.

    Read More

    Abcam Scientific Support

    回复于 Jun 05 2001

    Question

    I have 2 questions 1. What is the affinity constant for the antibody. 2. What is the concentration of antibody in a sample. Thank you.

    Read More

    Abcam community

    Verified customer

    Asked on Nov 02 2000

    Answer

    The affinity constant for this antibody has not been determined. The concentration of antibody in the sample has not been determined and the material is supplied as a whole serum. This specific antibody has been used for the past 15 or so years for many publications including those listed in the datasheet and the dilution quoted on the datasheet is accurate (1/5000 working dilution).

    Read More

    Abcam Scientific Support

    回复于 Nov 06 2000

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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