存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
存储溶液Preservative: 0.1% Sodium azide
Concentration information loading...
纯化说明The antibody was purified by ammonium sulfate precipitation.
Our Abpromise guarantee covers the use of ab23570 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
|IHC-FoFr||Use at an assay dependent concentration. PubMed: 21346800|
|IHC-Fr||1/500. Fix fresh frozen sections with PFA.|
|WB||1/1000 - 1/2000. Predicted molecular weight: 7 kDa.|
功能Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium.
组织特异性In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.
序列相似性Belongs to the neurogranin family.
Contains 1 collagen-like domain.
Contains 1 IQ domain.
- Information by UniProt
- Protein kinase C substrate RC3 antibody
- Calmodulin binding protein antibody
- Hng antibody
ab23570 at 1/500 staining mouse embryonic mesencephalon tissue sections by IHC-Fr. The sections were paraformaldehyde fixed and incubated with the antibody for 12 hours. An Alexa Fluor ® 488 conjugated goat polyclonal antibody was used as the secondary.
This product has been referenced in:
- Chaney A et al. Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe ×PS1?e9 transgenic mouse model of Alzheimer's disease. J Neurochem 144:318-335 (2018). IHC ; Mouse . Read more (PubMed: 29124761) »
- Obana EA et al. Conditional deletion of Neurog1 in the cerebellum of postnatal mice delays inhibitory interneuron maturation. J Neurosci Res 96:1560-1575 (2018). Read more (PubMed: 29665106) »