Necrostatin-1,necroptosis抑制剂(ab141053)
Key features and details
- Potent, specific necroptosis inhibitor
- CAS Number: 4311-88-0
- Purity: > 99%
- Soluble in ethanol to 50 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Necrostatin-1,necroptosis抑制剂 -
描述
Potent,specific necroptosis抑制剂 -
生物学描述
Potent, specific necroptosis inhibitor (EC50 = 490 nM). Selective allosteric inhibitor of death domain receptor-associated adaptor kinase RIP1 in vitro (EC50 = 182 nM). Caspase independent, programmed necrosis pathway.
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纯度
> 99% -
CAS编号
4311-88-0 -
化学结构
性能
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化学名称
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone -
分子量
259.33 -
分子式
C13H13N3OS -
PubChem识别号
2828334 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in ethanol to 50 mM and in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
S=C3NC(Cc1cnc2ccccc12)C(=O)N3C -
来源
Synthetic
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研究领域
图片
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2D chemical structure image of ab141053, Necrostatin-1, necroptosis inhibitor
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Necroptosis exists in PDLSCs.
TEM, a representative normal cell (the cell had a long fusiform, cell membrane structure was complete, the nucleus was round, nucleolus was obvious and center), b representative necroptosis cell (cell membrane ruptured, organelle disappeared, chromatin consolidated and agglutinated, presenting necrotic ultrastructural characteristics), c representative necrosis cell after Nec-1 inhibited (the cell membrane was intact, and the chromatin structure returned to normal).
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (15)
ab141053 被引用在 15 文献中.
- Peters MC et al. Metabolic Maturation Increases Susceptibility to Hypoxia-induced Damage in Human iPSC-derived Cardiomyocytes. Stem Cells Transl Med 11:1040-1051 (2022). PubMed: 36018047
- Molnár T et al. Caspase-9 acts as a regulator of necroptotic cell death. FEBS J 288:6476-6491 (2021). PubMed: 33899329
- Lau H et al. Necrostatin-1 Supplementation to Islet Tissue Culture Enhances the In-Vitro Development and Graft Function of Young Porcine Islets. Int J Mol Sci 22:N/A (2021). PubMed: 34445075
- Lau H et al. The effects of necrostatin-1 on the in vitro development and function of young porcine islets over 14-day prolonged tissue culture. Xenotransplantation 28:e12667 (2021). PubMed: 33438288
- Yan S et al. Necroptosis pathway blockage attenuates PFKFB3 inhibitor-induced cell viability loss and genome instability in colorectal cancer cells. Am J Cancer Res 11:2062-2080 (2021). PubMed: 34094669