Key features and details
- Mouse monoclonal [M622709] to Natriuretic peptides A
- Suitable for: RIA, IHC-P
- Reacts with: Human
- Isotype: IgG1
存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
存储溶液Preservative: 0.1% Sodium azide
Concentration information loading...
纯度Protein A purified
Our Abpromise guarantee covers the use of ab2093 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|RIA||Use at an assay dependent concentration.|
|IHC-P||Use at an assay dependent concentration.|
功能Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
疾病相关Atrial standstill 2
Atrial fibrillation, familial, 6
序列相似性Belongs to the natriuretic peptide family.
翻译后修饰Cleaved by CORIN upon secretion to produce the functional hormone.
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.
- Information by UniProt
- ANF antibody
- ANF_HUMAN antibody
- ANP antibody
ab2093 被引用在 1 文献中.
- Therrien JP et al. A gene therapy approach for long-term normalization of blood pressure in hypertensive mice by ANP-secreting human skin grafts. Proc Natl Acad Sci U S A 107:1178-83 (2010). IHC-P, Flow Cyt ; Human . PubMed: 20080656