Native小鼠Factor X蛋白(ab96742)
Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Active: Yes
- Suitable for: SDS-PAGE, Functional Studies
描述
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产品名称
Native小鼠Factor X蛋白
参阅全部 Factor X 蛋白酶 -
生物活性
86.8 U/mg determined by Factor X clotting assay (1 unit is equivalent to the Factor X activity in 1 ml normal plasma based on a Human plasma standard curve). 86.8 U/mg determined by Factor X clotting assay (1 unit is equivalent to the Factor X activity in 1 ml normal plasma based on a Human plasma standard curve). -
纯度
> 95 % SDS-PAGE.
ab96742 is isolated from fresh frozen plasma by a combination of conventional techniques and immunoaffinity chromatography. -
表达系统
Native -
Accession
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蛋白长度
Full length protein -
无动物成分
No -
性质
Native -
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种属
Mouse -
预测分子量
59 kDa -
氨基酸
41 to 481
-
技术指标
Our Abpromise guarantee covers the use of ab96742 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
Functional Studies
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形式
Liquid -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituent: 50% Glycerol (glycerin, glycerine)
This product is an active protein and may elicit a biological response in vivo, handle with caution.
常规信息
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别名
- Activated factor Xa heavy chain
- Coagulation factor X
- F10
see all -
功能
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. -
组织特异性
Plasma; synthesized in the liver. -
疾病相关
Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. -
序列相似性
Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain. -
翻译后修饰
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. -
细胞定位
Secreted. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab96742 尚未被引用在任何文献中。