Native人Serum Albumin蛋白(FITC) (ab8030)
Key features and details
- Expression system: Native
- Suitable for: Dot blot, WB
描述
-
产品名称
Native人Serum Albumin蛋白(FITC)
参阅全部 Human Serum Albumin 蛋白酶 -
表达系统
Native -
Accession
-
蛋白长度
Full length protein -
无动物成分
No -
性质
Native -
-
种属
Human -
预测分子量
69 kDa
-
-
偶联物
FITC. Ex: 493nm, Em: 528nm -
描述
Native人人Serum Albumin蛋白(FITC)
技术指标
Our Abpromise guarantee covers the use of ab8030 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
应用
Dot blot
Western blot
-
形式
Lyophilized -
补充说明
Fluorochrome/Protein Ratio: 1.5 moles FITC per mole of Human Albumin.
AB8030 contains Polyethylene glycol at 10 mg/mL as a stabilizer.
-
Concentration information loading...
制备和贮存
-
稳定性和存储
Shipped at 4°C. Store at 4°C prior to reconstitution. Store at -20°C long term. Avoid freeze / thaw cycle. Reconstitute for long term storage.
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.87% Sodium chloride, 1% Polyethylene glycol -
复溶Reconstitute with 1.0 mL of deionized water
常规信息
-
别名
- alb
- ALBU_HUMAN
- Albumin
see all -
功能
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. -
组织特异性
Plasma. -
疾病相关
Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population. -
序列相似性
Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains. -
翻译后修饰
Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.
Glycated in diabetic patients.
Phosphorylation sites are present in the extracelllular medium.
Acetylated on Lys-223 by acetylsalicylic acid. -
细胞定位
Secreted. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
-
SDS download
-
Datasheet download
文献 (9)
ab8030 被引用在 9 文献中.
- Sutton MN et al. RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging. Mol Imaging Biol 24:498-509 (2022). PubMed: 34905147
- Liang X et al. Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models. J Extracell Vesicles 11:e12248 (2022). PubMed: 35879268
- Offeddu GS et al. Microphysiological endothelial models to characterize subcutaneous drug absorption. ALTEX N/A:N/A (2022). PubMed: 36533850
- Zhang SY & Mahler GJ Modelling Renal Filtration and Reabsorption Processes in a Human Glomerulus and Proximal Tubule Microphysiological System. Micromachines (Basel) 12:N/A (2021). PubMed: 34442605
- Bres EE et al. Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures. Glia 68:2517-2549 (2020). PubMed: 32579270
- Offeddu GS et al. An on-chip model of protein paracellular and transcellular permeability in the microcirculation. Biomaterials 212:115-125 (2019). PubMed: 31112823
- Offeddu GS et al. Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution. Small 15:e1902393 (2019). PubMed: 31497931
- Zadravec P et al. Development of Recombinant Lactococcus lactis Displaying Albumin-Binding Domain Variants against Shiga Toxin 1 B Subunit. PLoS One 11:e0162625 (2016). ELISA . PubMed: 27606705
- Homan KA et al. Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips. Sci Rep 6:34845 (2016). PubMed: 27725720