Anti-MMP13抗体[M33] (ab1010)
概述
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产品名称Anti-MMP13抗体[M33]
参阅全部 MMP13 一抗 -
描述小鼠单克隆抗体[M33] to MMP13
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宿主Mouse
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特异性Based on Western blotting, the antibody reacts with human procollagenase-3. The antibody does not cross react with MT1-MMP latent form (MMP-14), MT2-MMP catalytic domain (MMP-15), MT3-MMP catalytic domain (MMP-16), MT4-MMP catalytic domain (MMP-17), MT5-MMP catalytic domain (MMP-18), Gelatinase A (MMP-2) latent form, Gelatinase B (MMP-9) latent form or Collagenase 2 (MMP-8) latent form.
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经测试应用适用于: WB, ELISAmore details
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种属反应性与反应: Human
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免疫原
Recombinant human procollagenase-3 expressed in insect cells
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常规说明MMP is Matrix Metalloproteinase.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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存储溶液Preservative: 0.01% Sodium azide
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Concentration information loading... -
纯度Protein G purified
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克隆单克隆
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克隆编号M33
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同种型IgG1
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轻链类型unknown
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研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
Our Abpromise guarantee covers the use of ab1010 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/2000. Detects a band of approximately 50 kDa (predicted molecular weight: 53 kDa). | |
| ELISA | 1/2000. |
靶标
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功能Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.
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组织特异性Seems to be specific to breast carcinomas.
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疾病相关Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:602111]. A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age.
Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1) [MIM:602111]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. -
序列相似性Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains. -
结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
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细胞定位Secreted > extracellular space > extracellular matrix.
- Information by UniProt
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数据库链接
- Entrez Gene: 4322 Human
- Omim: 600108 Human
- SwissProt: P45452 Human
- Unigene: 2936 Human
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别名
- CLG 3 antibody
- CLG3 antibody
- Collagenase 3 antibody
see all
数据表及文件
文献
ab1010 has not yet been referenced specifically in any publications.
