MG-132 (Ethanol Solution),proteasome抑制剂(ab147047)
Key features and details
- Cell-permeable, potent, reversible proteasome inhibitor
- CAS Number: 133407-82-6
- Purity: > 98%
- Supplied in ethanol (10 mM)
- Form / State: Liquid
- Source: Synthetic
概述
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产品名称
MG-132 (Ethanol Solution),proteasome抑制剂 -
描述
Cell-permeable,potent,reversible proteasome抑制剂 -
别名
- Z-Leu-Leu-Leu-CHO
- Z-LLL-CHO
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生物学描述
Cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation. Anticancer properties in vitro and in vivo.
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纯度
> 98% -
常规说明
Desiccate at -20°C in a spark free freezer [product contains a flammable solvent (UN1170: ethanol solution, PG II)]. Protect from air and moisture.
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CAS编号
133407-82-6 -
化学结构
性能
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分子量
475.62 -
分子式
C26H41N3O5 -
序列
LLL (Modifications : N-terminal benzyloxycarbonyl; C-terminal aldehyde) -
PubChem识别号
462382 -
存放说明
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
溶解度概述
Supplied in ethanol (10 mM) -
处理
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
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实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (2)
ab147047 被引用在 2 文献中.
- Petrocelli JJ et al. Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail. Aging (Albany NY) 15:1808-1832 (2023). PubMed: 36947713
- Chen W et al. MARCH8 Suppresses Tumor Metastasis and Mediates Degradation of STAT3 and CD44 in Breast Cancer Cells. Cancers (Basel) 13:N/A (2021). PubMed: 34067416