Anti-Metabotropic Glutamate Receptor 2+3抗体(ab6438)
Key features and details
- Rabbit polyclonal to Metabotropic Glutamate Receptor 2+3
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-Metabotropic Glutamate Receptor 2+3抗体 -
描述
兔多克隆抗体to Metabotropic Glutamate Receptor 2+3 -
宿主
Rabbit -
特异性
This antibody recognises the monomer version (110kDa) and the dimer (220kDa) of Metabotropic Glutamate Receptor 2+3.
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经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat -
免疫原
Synthetic peptide corresponding to Metabotropic Glutamate Receptor 2+3 (C terminal) conjugated to keyhole limpet haemocyanin.
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阳性对照
- WB: Rat hippocampal lysate, HEK 293
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Constituents: 50% Glycerol, BSA, 0.24% HEPES, 4.41% Sodium chloride -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
Our Abpromise guarantee covers the use of ab6438 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/1000. Detects a band of approximately 100, 200 kDa. |
靶标
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相关性
L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. The activity of GRM2 and GRM3 receptors are mediated by a G-protein that inhibits adenylate cyclase activity. -
细胞定位
Integral membrane protein. -
数据库链接
- Entrez Gene: 24415 Rat
- Entrez Gene: 24416 Rat
- SwissProt: P31421 Rat
- SwissProt: P31422 Rat
- Unigene: 41715 Rat
- Unigene: 9681 Rat
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别名
- GLUR2 antibody
- GLUR3 antibody
- Glutamate receptor homolog antibody
see all
图片
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Western blot - Anti-Metabotropic Glutamate Receptor 2+3 antibody (ab6438)Anti-Metabotropic Glutamate Receptor 2+3 antibody (ab6438) at 1/1000 dilution + rat hippocampal lysate at 10 µgShowing the specific immunolabeling of the ~110k monomer and the ~220k dimer of Metabotropic Glutamate Receptor 2+3.
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Western blot - Anti-Metabotropic Glutamate Receptor 2+3 antibody (ab6438)All lanes : Anti-Metabotropic Glutamate Receptor 2+3 antibody (ab6438)
All lanes : HEK 293 cell expression
Lysates/proteins at 10 µg per lane.As shown in the autoradiograph, ab6438 recognizes both the ~110k monomer and the ~220k dimer of Metabotropic Glutamate Receptor 2 (Lane 1) and Metabotropic Glutamate Receptor 3 (Lane 2). Also shown is the specific immunolabeling of the monomer.
实验方案
文献 (10)
ab6438 被引用在 10 文献中.
- Onishi T et al. Acute spatial spread of NO-mediated potentiation during hindpaw ischaemia in mice. J Physiol 597:3441-3455 (2019). PubMed: 31087329
- Gonzalez-Reyes LE et al. Sonic Hedgehog is expressed by hilar mossy cells and regulates cellular survival and neurogenesis in the adult hippocampus. Sci Rep 9:17402 (2019). PubMed: 31758070
- Lu Y et al. Activity-dependent synaptic integration and modulation of bilateral excitatory inputs in an auditory coincidence detection circuit. J Physiol 596:1981-1997 (2018). PubMed: 29572827
- Jin LE et al. mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions. Mol Psychiatry 22:1615-1625 (2017). PubMed: 27502475
- Goniotaki D et al. Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity. PLoS Pathog 13:e1006733 (2017). PubMed: 29176838
- Amat SB et al. Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice. PLoS One 12:e0179347 (2017). IHC ; Mouse . PubMed: 28658323
- Houck BD & Person AL Cerebellar Premotor Output Neurons Collateralize to Innervate the Cerebellar Cortex. J Comp Neurol 523:2254-71 (2015). PubMed: 25869188
- Chen YW et al. Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism. Front Behav Neurosci 8:219 (2014). WB ; Rat . PubMed: 24987341
- Tang ZQ et al. Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons. J Neurosci 33:15964-77 (2013). PubMed: 24089501
- Williams PA et al. Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity. Brain 135:493-505 (2012). WB, IHC-Fr ; Mouse . PubMed: 22300878
