Key features and details
- Mouse monoclonal [HBME-1] to Mesothelioma
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgM
参阅全部 Mesothelioma 一抗
描述小鼠单克隆抗体[HBME-1] to Mesothelioma
特异性This antibody reacts with an unknown antigen on microvilli of mesothelioma cells. It stains normal mesothelial cells as well as epithelial mesothelimias in a thick membrane pattern due to abundant lung microvilli on the surface of these cells.
Tested Applications & Species
Application Species IHC-PHuman
Suspension of human mesothelioma cells from patients with malignant epithelial mesothelioma.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.
One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.
Learn more here.
存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
存储溶液Preservative: 0.05% Sodium azide
Constituent: 1% BSA
Concentration information loading...
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab2383 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
We suggest an incubation period of 60 minutes at room temperature.
However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions and antibody dilutions should be determined by the user.
Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.
相关性Mesothelioma is a rare form of carcinoma of the mesothelial cells which that normally line the body cavities, including the pleura, peritoneum, pericardium, and testis. It may be localized or diffuse. Most, but not all, cases of pleural malignant mesothelioma are associated with asbestos exposure.
- Malignant mesothelioma susceptibility to antibody
- MMS antibody
ab2383 被引用在 1 文献中.
- Chernova T et al. Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf). Curr Biol 27:3302-3314.e6 (2017). PubMed: 29112861