Anti-Mesothelin抗体(ab96869)
Key features and details
- Rabbit polyclonal to Mesothelin
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
-
产品名称
Anti-Mesothelin抗体
参阅全部 Mesothelin 一抗 -
描述
兔多克隆抗体to Mesothelin -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Recombinant protein fragment corresponding to a region within amino acids 44 and 438 of Human Mesothelin (NP_037536).
-
阳性对照
- WB: 293T cell lysate IHC-P: serous OVCA
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab96869于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/500 - 1/3000. Predicted molecular weight: 69 kDa.
|
|
IHC-P |
1/100.
|
说明 |
---|
WB
1/500 - 1/3000. Predicted molecular weight: 69 kDa. |
IHC-P
1/100. |
靶标
-
功能
Membrane-anchored forms may play a role in cellular adhesion.
Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. -
组织特异性
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). -
疾病相关
Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. -
序列相似性
Belongs to the mesothelin family. -
翻译后修饰
Both MPF and the cleaved form of mesothelin are N-glycosylated.
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. -
细胞定位
Secreted and Cell membrane. Golgi apparatus. - Information by UniProt
-
数据库链接
- Entrez Gene: 10232 Human
- Omim: 601051 Human
- SwissProt: Q13421 Human
- Unigene: 408488 Human
-
别名
- CAK 1 antibody
- CAK1 antibody
- CAK1 antigen antibody
see all
图片
数据表及文件
-
SDS download
-
Datasheet download
文献 (2)
ab96869 被引用在 2 文献中.
- Feng F et al. Level of mesothelin expression can indicate the prognosis of malignant pleural mesothelioma. Transl Cancer Res 9:7479-7485 (2020). PubMed: 35117348
- He X et al. Role of mesothelin in carbon nanotube-induced carcinogenic transformation of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 311:L538-49 (2016). PubMed: 27422997