Anti-MCT2抗体(ab129290)
Key features and details
- Goat polyclonal to MCT2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-MCT2抗体
参阅全部 MCT2 一抗 -
描述
山羊多克隆抗体to MCT2 -
宿主
Goat -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Chimpanzee, Monkey, Gorilla, Common marmoset -
免疫原
Synthetic peptide:
SNAQSVTSERETNI
with a Cysteine residue linker, corresponding to C terminal amino acids 465-478 of Human MCT2 (NP_004722.2). -
阳性对照
- Human testis tissue; A549 lysate.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading...
-
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab129290于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 52 kDa.
|
|
IHC-P |
Use a concentration of 2.5 - 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
|
说明 |
---|
WB
Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 52 kDa. |
IHC-P
Use a concentration of 2.5 - 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
-
功能
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter. -
组织特异性
High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells. -
序列相似性
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. -
细胞定位
Cell membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 9194 Human
- Omim: 603654 Human
- SwissProt: O60669 Human
- Unigene: 439643 Human
-
别名
- MCT 2 antibody
- MCT antibody
- Monocarboxylate transporter 2 antibody
see all
图片
数据表及文件
-
Datasheet download
文献 (3)
ab129290 被引用在 3 文献中.
- Giatromanolaki A et al. Programmed death-1 receptor (PD-1) and PD-ligand-1 (PD-L1) expression in non-small cell lung cancer and the immune-suppressive effect of anaerobic glycolysis. Med Oncol 36:76 (2019). PubMed: 31342270
- Lund J et al. Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism. Sci Rep 8:9814 (2018). PubMed: 29959350
- Eilertsen M et al. Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival. PLoS One 9:e105038 (2014). IHC-P ; Human . PubMed: 25225794